HA6985 Phosphatidylserine Powder (PS)

Phosphatidylserine (PS) Description

Phosphatidylserine appears as a fine, hygroscopic powder. Its colour ranges from off‐white to pale yellow. It can also exist as a viscous amber liquid. It exhibits little odour; however, in its crude form it presents a slight soybean aroma.

Its structure comprises a serine headgroup attached to two fatty acid chains via a glycerol backbone. This structure imparts amphiphilic properties. Consequently, the compound forms bilayers in aqueous environments.

The compound disperses in water, forming micelles. It dissolves well in chloroform‐methanol mixtures; its solubility in pure hydrocarbons is limited.

It is susceptible to oxidation because of unsaturated fatty acids. Therefore, nitrogen‐flushed packaging is required. Storage must be maintained below –20°C. Tocopherols are added as antioxidants.

Its performance is pH‐dependent. Its integrity is maintained between pH 6 and pH 8. It hydrolyses under strongly acidic or alkaline conditions.

High-performance liquid chromatography with evaporative light scattering detection (HPLC-ELSD) reveals purities above 50%. Soy-derived samples are predominated by C18 fatty acids, especially linoleic and oleic acids. Sunflower-derived samples contain greater amounts of palmitic acid.

Sensory evaluation indicates a mild umami note and slight bitterness. It performs as an emulsifier and modulates membrane fluidity. The impurity profile requires strict control. Lysophospholipid content must remain below 3%. Residual solvents are controlled to be under 50 ppm.

Phosphatidylserine (PS) Applications

• Nutraceuticals: Formulations in capsules, tablets, and gummies aim to enhance cognitive function, support age-related memory, and assist in ADHD management.
• Sports Nutrition: The compound is added to pre-workout formulations and recovery supplements. Studies indicate a reduction in exercise-induced cortisol and improved endurance.
• Functional Foods: Brain-health beverages, nutrition bars, and dairy products incorporate this compound for daily cognitive maintenance.
• Pediatric Supplements: Chewable and liquid formulations are developed for children and adolescents to enhance focus.
• Veterinary Health: Cognitive support formulations for ageing pets and performance animals include this compound.

Phosphatidylserine (PS) Packaging

Products are packaged in customised cartons. The carton sizes depend on the material dimensions. Small items are placed in polypropylene boxes, while larger items are secured in customised wooden crates. Appropriate cushioning materials are used to ensure transport protection.

Packaging options include cartons, wooden boxes, or customised solutions.

Please review the packaging details provided for reference.

Manufacturing Process

1.       Testing Method

(1)     Chemical composition analysis is performed. Techniques, including GDMS or XRF, are employed to ensure compliance with purity requirements.

(2)     Mechanical properties are assessed. Tests for tensile strength, yield strength, and elongation are conducted to evaluate material performance.

(3)     Dimensional inspection is conducted. Thickness, width, and length are measured to verify that specified tolerances are met.

(4)     Surface quality is examined by visual and ultrasonic analysis to detect scratches, cracks, or inclusions.

(5)     Hardness testing is carried out to determine material consistency and mechanical reliability.

Please refer to the SAM testing procedures for further details.

Phosphatidylserine (PS) FAQs

Q1. Is soy-derived PS safe for those with soy allergies?

Highly purified PS contains minimal soy proteins. For individuals with severe allergies, sunflower-derived PS is recommended. Clinical studies indicate no cross-reactivity when pharmaceutical-grade purity is achieved.

Q2. How soon should I expect mental clarity benefits?

Acute effects on focus may be observed within 1–2 hours after administration. Sustained improvements in memory recall typically require 3–6 weeks of consistent supplementation.

Q3. Can I bake with PS powder without losing efficacy?

Temperatures exceeding 150°C should be avoided. For baked goods, incorporate PS into fillings or apply it as a topping after baking, given that prolonged heat degrades phospholipid structures.

Related Information

Common Preparation Methods

Phosphatidylserine is produced using enzymatic transphosphatidylation. Soy or sunflower lecithin is purified to isolate phosphatidylcholine (PC). PC reacts with L-serine in a bioreactor. Phospholipase D (e.g., Streptomyces spp.) is employed at 45–55°C for 12–24 hours. The PS-enriched mixture is separated by centrifugation. Solvent extraction with hexane/ethanol removes triglycerides. Silica gel chromatography is used to achieve concentrations above 50% PS. The eluate is decolourised with activated carbon. Vacuum distillation removes solvents subsequently. For emulsifiable liquids, high-pressure homogenisation is applied; alternatively, spray-drying with rice maltodextrin is used for powders. Fatty acid profiling and residual enzyme testing are conducted for quality control.