CORM-3 Powder Description
The enzymatic reaction of haem oxygenase provided the basis for developing synthetic CORMs. The initial synthetic CORMs were, in most cases, metal carbonyl complexes. One representative CORM has been studied in biochemical and pharmacological investigations. It is the Ruthenium(II) complex Ru(glycinat)Cl(CO)3, known as CORM-3.
The CORM-3 powder is a water-soluble carbon monoxide (CO)-releasing molecule used to examine the effects of CO on cellular systems. Carbon monoxide (CO) is produced during the degradation of haem by the enzyme haem oxygenase. It has recently been identified as an important gaseous signalling molecule in mammalian cells. CORM-3 has been shown to reduce inflammation and offers cardioprotective effects.

CORM-3 Powder Specifications
CAS Number
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475473-26-8
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Molecular Formula
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C5H4ClNO5Ru
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Molecular Weight
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294.61
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Synonyms
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Carbon monoxide-releasing molecule 3, Tricarbonylchloro(glycinat)ruthenium (II)
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Appearance
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White Powder
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Solubility
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H2O: 20 mg/mL, clear
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CORM-3 Powder Applications
CORM-3 (carbon monoxide (CO)-releasing molecule-3) has been used to study its effect on the activation of the NLRP3 inflammasome via glycolysis in macrophages, and its influence on hyperglycaemia-induced IL-1β production. CORM-3 powder has also been used to assess its function in protecting primary rabbit lens epithelial cells against H2O2-induced apoptosis.
CORM-3 Powder Safety Information
RIDADR
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NONH for all modes of transport
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WGK Germany
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3
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