A simple, multidimensional approach to high-throughput discovery of catalytic reactions.

Title	A simple, multidimensional approach to high-throughput discovery of catalytic reactions.
Authors	Daniel Robbins, John Hartwig
Magazine	Science (New York, N.Y.)
Date	09/09/2011
DOI	10.1126/science.1207922
Introduction	Transition metal complexes serve as catalysts in crucial reactions utilised across various fields such as medicine, materials science, and energy production. Despite the significant attention given to high-throughput methods for catalyst identification, these approaches have not been widely implemented in synthetic laboratories due to their complexity and accessibility issues. This study introduces a straightforward methodology for assessing a wide array of catalysts for potential coupling reactions using basic laboratory equipment. By screening different catalysts and ligands with a diverse substrate mixture, and employing mass spectrometry to identify reaction products, it was found that copper-catalysed alkyne hydroamination and nickel-catalysed hydroarylation reactions demonstrate excellent functional-group tolerance.
Quote	Daniel W Robbins and John F Hartwig. A simple, multidimensional approach to high-throughput discovery of catalytic reactions.. 2011. DOI: 10.1126/science.1207922
Element	Copper (Cu) , Nickel (Ni)
Topics	High-Throughput Screening of Materials
Industry	Chemical & Pharmacy , Research & Laboratory