Copper, chromium, manganese, iron, nickel, and zinc levels in biological samples of diabetes mellitus patients.

Title	Copper, chromium, manganese, iron, nickel, and zinc levels in biological samples of diabetes mellitus patients.
Authors	Tasneem Gul Kazi, Hassan Imran Afridi, Naveed Kazi, Mohammad Khan Jamali, Mohammad Bilal Arain, Nussarat Jalbani, Ghulam Abbas Kandhro
Magazine	Biological trace element research
Date	04/01/2008
DOI	10.1007/s12011-007-8062-y
Introduction	Emerging evidence suggests altered trace element metabolism in diabetes mellitus, potentially influencing disease pathogenesis and progression. This study assessed the levels of essential trace elements, including chromium (Cr), copper (Cu), iron (Fe), manganese (Mn), nickel (Ni), and zinc (Zn), in biological samples (whole blood, urine, and scalp hair) of patients with type 2 diabetes mellitus (n=257) compared to nondiabetic controls (n=166) aged 45-75 years and both genders. Element concentrations were determined using an atomic absorption spectrophotometer following microwave-induced acid digestion. Validity and accuracy were confirmed via conventional wet-acid-digestion and certified reference materials, with recovery rates ranging from 97.60-99.49% of certified values. Results revealed significantly reduced Zn, Mn, and Cr levels in blood and scalp hair of diabetic patients versus controls (p < 0.001), with elevated urinary levels in diabetics. Conversely, higher Cu and Fe levels were noted in diabetic scalp hair and blood, though blood differences were not statistically significant (p < 0.05). These findings align with other studies, suggesting trace metal deficiencies and excesses may contribute to diabetes mellitus development.
Quote	Tasneem Gul Kazi, Hassan Imran Afridi and Naveed Kazi et al. Copper, chromium, manganese, iron, nickel, and zinc levels in biological samples of diabetes mellitus patients. Biol Trace Elem Res. 2008. Vol. 122(1). DOI: 10.1007/s12011-007-8062-y
Element	Chromium (Cr) , Copper (Cu) , Manganese (Mn) , Nickel (Ni) , Zinc (Zn)
Industry	Medical Devices