Glyphosate, pathways to modern diseases II: Coeliac disease and gluten intolerance

Title	Glyphosate, pathways to modern diseases II: Coeliac disease and gluten intolerance
Authors	Anthony Samsel, Stephanie Seneff
Magazine	Interdisciplinary Toxicology
Date	12/01/2013
DOI	10.2478/intox-2013-0026
Introduction	Celiac disease and gluten intolerance are increasingly prevalent globally, particularly in North America and Europe, affecting an estimated 5% of the population. This multifactorial condition manifests with symptoms such as nausea, diarrhoea, skin rashes, macrocytic anaemia, and depression, and is linked to various nutritional deficiencies, reproductive challenges, and elevated risks of thyroid disease, kidney failure, and cancer. This paper posits that glyphosate, the active component in Roundup® herbicide, serves as a primary driver of this rising health concern. Observations of digestive issues in fish exposed to glyphosate correspond with those seen in celiac disease. Furthermore, the gut bacterial imbalances characteristic of celiac disease align with glyphosate's known impact on gut microbiota. Celiac disease often involves compromised cytochrome P450 enzymes, crucial for detoxifying environmental compounds, activating vitamin D3, processing vitamin A, and maintaining bile acid and sulphate levels in the gut; glyphosate is known to inhibit these enzymes. The deficiencies in essential elements such as iron, cobalt, molybdenum, copper, and other trace metals observed in celiac patients can be attributed to glyphosate's potent chelating properties. Similarly, the reduced levels of amino acids such as tryptophan, tyrosine, methionine, and selenomethionine in celiac disease correspond with glyphosate's known effect of depleting these compounds. An elevated risk of non-Hodgkin's lymphoma in celiac patients also parallels concerns regarding glyphosate exposure. Reproductive issues, including infertility, miscarriages, and birth defects, also align with potential glyphosate influence. Recent increases in glyphosate residues in crops such as wheat are likely due to the growing practice of pre-harvest crop desiccation. The paper further suggests that glyphosate use for "ripening" sugar cane could contribute to the recent rise in kidney failure among agricultural workers in Central America, urging governments to review policies on glyphosate residues in food for public safety.
Quote	Anthony Samsel and Stephanie Seneff. Glyphosate, pathways to modern diseases II: Celiac sprue and gluten intolerance. Interdisciplinary Toxicology. 2013. Vol. 6(4):159-184. DOI: 10.2478/intox-2013-0026
Element	Cobalt (Co) , Molybdenum (Mo) , Copper (Cu) , Selenium (Se) , Sulfur (S)
Materials	Chemical Compounds , Rare Earth Metals
Topics	Biomedical Materials , Catalytic Materials
Industry	Agriculture , Chemical & Pharmacy , Pharmaceutical Industry , Research & Laboratory