Male reproductive effect of nickel sulphate in mice.

Title	Male reproductive effect of nickel sulphate in mice.
Authors	R Pandey, R Kumar, S P Singh, D K Saxena, S P Srivastava
Magazine	Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine
Date	12/01/1999
DOI	10.1023/a:1009291816033
Introduction	In this study, adult male mice were orally exposed to nickel sulphate at doses of 5 and 10 mg/kg body weight for 35 days. Despite no changes in body weight, the exposure led to significant reductions in the absolute and organ-to-body weight ratios of reproductive organs, including the testes, epididymides, seminal vesicles, and prostate gland. Additionally, sperm abnormalities, decreased sperm motility, and lower sperm counts were recorded. Enzymatic activity in the testes was notably altered, with decreases in sorbitol dehydrogenase and increases in lactate dehydrogenase and gamma-glutamyl transpeptidase. Histopathological changes were evident, alongside nickel accumulation in the reproductive tissues, indicating potential histological damage and spermatotoxic effects. These findings suggest that oral intake of nickel can detrimentally impact male reproductive health, potentially leading to developmental toxic effects mediated by males.
Quote	R Pandey, R Kumar and S P Singh et al. Male reproductive effect of nickel sulphate in mice. Biometals: an international journal on the role of metal ions in biology, biochemistry, and medicine. 1999. Vol. 12(4). DOI: 10.1023/a:1009291816033
Element	Nickel (Ni)