Nickel absorption and kinetics in human volunteers.

Title	Nickel absorption and kinetics in human volunteers.
Authors	Steven B Most, J P Creason, Zachary K Sweeney, Matthew Marcus, S M Hopfer, F W Sunderman
Magazine	Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (London, England)
Date	04/30/1989
DOI	10.3181/00379727-191-42881
Introduction	In this study, the kinetics of nickel absorption, distribution, and elimination were modelled in healthy human volunteers ingesting nickel sulfate (NiSO4) through drinking water and food. Electrothermal atomic absorption spectrophotometry was employed to analyse nickel in serum, urine, and faeces over a 6-day period. The study revealed that nickel absorption was significantly higher when ingested in water compared to food, demonstrating a profound reduction in bioavailability when dietary constituents are present. The study provides valuable kinetic parameters, reducing uncertainty in toxicological risk assessments of nickel exposure from water and food.
Quote	Steven B Most, J P Creason, Zachary K Sweeney, Matthew Marcus, S M Hopfer, F W Sunderman. Nickel absorption and kinetics in human volunteers.. 1989. DOI: 10.3181/00379727-191-42881
Element	Nickel (Ni)