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Streptothricin F is a bactericidal antibiotic effective against highly drug-resistant gram-negative bacteria that interacts with the 30S subunit of the 70S ribosome

Title	Streptothricin F is a bactericidal antibiotic effective against highly drug-resistant gram-negative bacteria that interacts with the 30S subunit of the 70S ribosome
Authors	Christopher E. Morgan, Yoon-Suk Kang, Alex B. Green, Kenneth P. Smith, Matthew G. Dowgiallo, Brandon C. Miller, Lucius Chiaraviglio, Katherine A. Truelson, Katelyn E. Zulauf, Shade Rodriguez, Anthony D. Kang, Roman Manetsch, Edward W. Yu, James E. Kirby
Magazine	PLOS Biology
Date	05/16/2023
DOI	10.1371/journal.pbio.3002091
Introduction	The emergence of highly drug-resistant gram-negative bacteria presents a significant global health challenge, necessitating the development of novel antimicrobial agents. Streptothricin F has been identified as a potent bactericidal antibiotic with efficacy against these challenging pathogens. This research focuses on characterising the mechanism by which Streptothricin F exerts its antibacterial effects, specifically detailing its interaction with the 30S subunit of the bacterial 70S ribosome. Understanding this precise molecular engagement is crucial for advancing the design of new antibiotics capable of overcoming existing resistance mechanisms and addressing the urgent need for effective treatments against resilient bacterial infections.
Quote	Morgan, C. E.; Kang, Y.-S.; Green, A. B.; Smith, K. P.; Dowgiallo, M. G.; Miller, B. C.; Chiaraviglio, L.; Truelson, K. A.; Zulauf, K. E.; Rodriguez, S.; Kang, A. D.; Manetsch, R.; Yu, E. W.; Kirby, J. E. Streptothricin F is a bactericidal antibiotic that
Industry	Pharmaceutical Industry , Research & Laboratory

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