Effects of Titanium Dioxide Nanoparticles Exposure on Human Health—a Review

Title	Effects of Titanium Dioxide Nanoparticles Exposure on Human Health—a Review
Authors	Ewa Baranowska-Wójcik, Dominik Szwajgier, Patryk Oleszczuk, Anna Winiarska-Mieczan
Magazine	Biological Trace Element Research
Date	04/13/2019
DOI	https://doi.org/10.1007/s12011-019-01706-6
Introduction	The rapid expansion of nanotechnology applications across various domains such as medicine, materials science, and agriculture has inevitably led to increased human exposure to nanoparticles (NPs). Research indicates that following inhalation or ingestion, nanoparticles can accumulate in vital organs including the lungs, liver, and kidneys, and disrupt metabolic functions in laboratory animals. Titanium dioxide nanoparticles (TiO2 NPs), commonly used in the food industry due to their white pigment (E171), are particularly prevalent. Although the health risks associated with dietary NPs are not fully understood, their toxicity is believed to be influenced by size, morphology, and quantity. Studies suggest that TiO2 NPs can provoke oxidative stress-induced inflammation and possess genotoxic properties, potentially causing apoptosis and chromosomal instability. This review synthesises existing research on the biological impact of TiO2 NPs, emphasising the need to evaluate the potential human health hazards posed by inorganic nanoparticles.
Quote	Ewa Baranowska-Wójcik, Dominik Szwajgier, Patryk Oleszczuk et al. Effects of Titanium Dioxide Nanoparticles Exposure on Human Health—a Review. Biol Trace Elem Res. 2019. Vol. 193(1):118-129. DOI: 10.1007/s12011-019-01706-6
Element	Titanium (Ti)
Materials	Oxides
Topics	Nanoparticles
Industry	Pharmaceuticals & Cosmetics , Chemical & Pharmacy