Rhodium-Catalysed Ketone Methylation Using Methanol Under Mild Conditions: Formation of α-Branched Products

Title	Rhodium-Catalysed Ketone Methylation Using Methanol Under Mild Conditions: Formation of α-Branched Products
Authors	Louis K M Chan, Darren L Poole, Di Shen, Mark P Healy, Timothy J Donohoe
Magazine	Angewandte Chemie (International Ed. in English)
Date	11/29/2013
DOI	10.1002/anie.201307950
Introduction	The rhodium-catalysed methylation of ketones has been effectively achieved using methanol as the methylating agent and the hydrogen-borrowing method. This process is significant due to its operation at relatively low temperatures and its ability to easily form α-branched products. Furthermore, doubly alkylated ketones can be synthesised from methyl ketones and two different alcohols using a sequential one-pot iridium- and rhodium-catalysed process.
Quote	Louis K M Chan, Darren L Poole and Di Shen et al. Rhodium-Catalysed Ketone Methylation Using Methanol Under Mild Conditions: Formation of α-Branched Products. Angew. Chem. Int. Ed. Engl. 2013. Vol. 53(3):761-765. DOI: 10.1002/anie.201307950
Element	Rhodium (Rh) , Iridium (Ir) , Hydrogen (H) , Carbon (C)
Materials	Chemical Compounds
Industry	Chemical & Pharmacy , Research & Laboratory

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