HA6972 Artemisinic Acid Powder (CAS No. 80286-58-4).

Artemisinic Acid Powder (CAS No. 80286-58-4) Description

Artemisinic Acid Powder appears as a white to off‐white crystalline solid. It exhibits a modest herbal odour that originates from its botanical source. The powder demonstrates a melting point range of 142–145°C and decomposes above 200°C without boiling. It shows limited solubility in water and readily dissolves in polar organic solvents including methanol, ethanol, acetone and dimethyl sulfoxide, while it remains insoluble in non‐polar solvents such as hexane or petroleum ether. Chemically, the compound is classified as a sesquiterpene lactone precursor with the molecular formula C15H22O2. Its structure comprises a decalin core that bears a carboxylic acid group and an unsaturated double bond conjugated to a methylene bridge. This molecular configuration renders the compound sensitive to light‐induced oxidation and thermal isomerisation, particularly under acidic or alkaline conditions. Crystallographic analysis establishes an orthorhombic crystal habit with hydrogen‐bonded dimer formation in the solid state. Ultraviolet analysis displays absorption maxima at 210 and 260 nanometres, while infrared spectroscopy reveals characteristic bands for carbonyl stretch (around 1700 cm⁻¹), carboxylic hydroxyl (near 3200 cm⁻¹) and alkene bonds (at 1640 cm⁻¹). The powder maintains moderate stability when stored in darkness at low temperatures, though it gradually yellows on exposure to air and moisture due to oxidation at the exocyclic methylene group. Its particle morphology generally ranges from fine needles to prismatic crystals, with a bulk density of approximately 0.5 grams per cubic centimetre.

Artemisinic Acid Powder (CAS No. 80286-58-4) Applications

Pharmaceutical Industry: Artemisinic acid is the essential precursor in the semi‐synthesis of artemisinin‐based antimalarial drugs, thereby providing a scalable and cost‐efficient alternative to plant extraction for global malaria treatment.

Cosmetics and Skincare Industry: It is incorporated into anti‐ageing and ultraviolet protective formulations for its antioxidant activity, thereby reducing oxidative skin damage and decelerating collagen degradation to support skin elasticity.

Agriculture and Pesticides Industry: Employed as a natural biopesticide against fungal pathogens and insect larvae, the compound offers residue‐free crop protection and enhances plant disease resistance.

Materials Science Industry: It is utilised in the synthesis of biodegradable polymers and functional nanomaterials. Its sesquiterpene backbone is specifically used to develop environmentally acceptable coatings and biomedical devices.

Industrial Biotechnology: Artemisinic acid is applied in engineered yeast fermentation systems. This approach has been proven to achieve high‐yield biosynthesis and consequently optimise artemisinin production efficiency.

Veterinary Medicine: The compound is developed as an antiparasitic agent for livestock to address infections such as babesiosis and is also integrated into aquaculture feeds to improve disease resistance in fish.

Research and Development: It is employed in studies concerning radiation injury mitigation and functions as a reference standard in analytical chemistry for quantifying bioactive compounds in pharmacological research.

Artemisinic Acid Powder (CAS No. 80286-58-4) Packaging

Our products are supplied in customised cartons of varying sizes based on the material dimensions. Small items are securely placed in PP boxes, whereas larger items are packed in customised wooden crates. We adhere to strict packaging customisation protocols and utilise suitable cushioning materials to ensure optimal protection during transportation.

Packaging: Carton, Wooden Box, or Customized.

Kindly review the packaging details provided for your reference.

Manufacturing Process

1.       Testing Method

(1)    Chemical Composition Analysis – The composition is verified using techniques such as GDMS or XRF to ensure compliance with purity requirements.

(2)    Mechanical Properties Testing – This includes tensile strength, yield strength and elongation tests to assess the material performance.

(3)    Dimensional Inspection – Thickness, width and length are measured to ensure adherence to specified tolerances.

(4)    Surface Quality Inspection – Defects such as scratches, cracks or inclusions are detected through visual and ultrasonic examinations.

(5)    Hardness Testing – Material hardness is determined to confirm uniformity and mechanical reliability.

Please refer to the SAM testing procedures for detailed information.

Artemisinic Acid Powder (CAS No. 80286-58-4) FAQs

Q1. What are its core properties?

The powder exhibits a melting point range of 142–145°C and decomposes above 200°C without boiling. It dissolves in polar solvents (methanol, ethanol, DMSO) but not in water or hexane. Its structure contains conjugated double bonds that are sensitive to light‐induced oxidation, which causes yellowing upon exposure to air. Infrared spectroscopy displays a carbonyl peak at approximately 1700 cm⁻¹ and a carboxylic hydroxyl peak near 3200 cm⁻¹.

Q2. Is it safe?

Appropriate safety measures are required when handling the powder. It may cause eye and skin irritation, and ingestion might result in nausea or dizziness. Severe toxicity has not been documented at industrial exposure levels; however, inhalation should be avoided. The substance should be stored away from oxidising agents.

Q3. How does it differ from artemisinin?

Artemisinic acid does not possess the endoperoxide bridge that is present in artemisinin, rendering it non‐antimalarial. It is the direct chemical precursor; conversion to artemisinin requires either photo‐oxidation or enzymatic steps.

Related Information

1.       Common Preparation Methods

Artemisinic acid powder is primarily extracted from the dried leaves of Artemisia annua L. using hydroalcoholic solvents (for example, 70–90% ethanol or methanol) under reflux at 60–80°C. The crude extract is filtered and concentrated under reduced pressure, followed by liquid–liquid partitioning with non‐polar solvents such as hexane to remove lipids. Further purification is carried out using silica gel column chromatography with gradient elution (ethyl acetate/hexane) or preparative HPLC to isolate artemisinic acid. The gathered fractions are acidified to a pH of 3–4 to precipitate impurities, and crystallisation is effected from an ethanol–water mixture (7:3 v/v) at low temperature. Recrystallisation yields a product with a purity of ≥98%, which is then vacuum‐dried at 40°C and milled into a fine powder. On an industrial scale, production may utilise engineered yeast (Saccharomyces cerevisiae) fermentation that expresses amorpha-4,11-diene synthase and cytochrome P450 enzymes to biosynthesise artemisinic acid, followed by extraction and equivalent purification. The final pharmaceutical‐grade powder is validated by HPLC-UV against reference standards, with residual solvents meeting ICH guidelines.