HA6980 Salvia Miltiorrhiza Extract Powder

Salvia Miltiorrhiza Extract Description

The extract is obtained from the roots of Salvia miltiorrhiza Bunge by means of an ethanol-water extraction (70:30 v/v) and subsequent spray-drying. The result is a fine, free‐flowing powder with a reddish‐brown colour and a homogeneous particle size distribution (95% passing 100‐mesh sieve). Its main active constituents are lipophilic tanshinones, which are standardised to a total concentration of 15% with cryptotanshinone at no less than 8%, in addition to hydrophilic salvianolic acids including rosmarinic acid and salvianolic acid B. The extract demonstrates solubility greater than 98% in aqueous matrices over a pH range of 3.0 to 7.0 and forms stable colloidal solutions without precipitation under standard processing conditions.

Thermal stability tests show that the extract retains its chemical integrity at temperatures ≤80°C for up to 120 minutes. Prolonged exposure above this temperature leads to degradation of the diterpenoid quinones. The low moisture content (<5% determined by Karl Fischer titration) limits hygroscopicity. The bulk density is measured between 0.45–0.55 g/cm³, which permits consistent volumetric dosing. Analytical characterisation by HPLC-UV yields distinct fingerprint chromatograms for tanshinone I, IIA, and cryptotanshinone that serve as quality control markers. The extract remains chemically stable for 24 months when stored in airtight containers, protected from light and maintained at ambient temperatures below 25°C, with no significant change in dissolution kinetics or polymorphic form. Residual solvent levels are within ICH Q3C limits, with ethanol content below 500 ppm.

Salvia Miltiorrhiza Extract Applications

• Functional Foods and Beverages: The extract is incorporated into antioxidant‐fortified juice formulations and fermented dairy products. Its high solubility (>98%) and stability across pH 3.0–7.0 allow for measured use in ready‐to‐drink beverages and meal replacement shakes aimed at circulatory support.
• Dietary Supplement Manufacturing: The extract is used in cardiovascular health capsules and sublingual tinctures. Standardised tanshinone content, including cryptotanshinone at ≥8%, is maintained for formulations that target the nitric oxide pathway, with tablet and softgel products produced according to precise dosage requirements.
• Cosmeceutical Development: Formulations such as anti‐redness serums and age‐delay creams are manufactured using the extract. Cryptotanshinone, included at concentrations between 0.2% and 0.5%, has been shown in research to reduce MMP-1 expression and IL-6 markers, thereby reducing visible erythema in subjects with rosacea.
• Pharmaceutical Research Ingredients: The extract is deployed as a reference standard in preclinical studies. It is used in experiments designed to measure platelet aggregation and endothelial function in thrombosis and angiogenesis assays.
• Veterinary Nutraceuticals: The extract is added to joint health formulations for companion animals and circulatory supplements for equines. Its demonstrated thermal stability permits its use during extrusion processing.

Salvia Miltiorrhiza Extract Packaging

Products are packaged in customised cartons that vary in size according to the dimensions of the material. Small items are placed in PP boxes, whereas larger items are secured in custom wooden crates. Packaging customisation and the use of appropriate cushioning materials are strictly controlled to ensure optimal protection during transportation.

Packaging: Carton, Wooden Box, or Customized.

Kindly review the packaging details provided for your reference.

Manufacturing Process

1.       Testing Method

(1)    Chemical Composition Analysis – Techniques such as GDMS or XRF are employed to verify compliance with purity requirements.

(2)    Mechanical Properties Testing – Tensile strength, yield point, and elongation tests are conducted to assess the material’s performance.

(3)    Dimensional Inspection – Measurements of thickness, width, and length are performed to ensure that specified tolerances are met.

(4)    Surface Quality Inspection – Visual and ultrasonic examinations are used to detect scratches, cracks, or inclusions.

(5)    Hardness Testing – The material’s hardness is determined to confirm uniformity and mechanical reliability.

Please refer to the SAM testing procedures for detailed information.

Salvia Miltiorrhiza Extract FAQs

Q1. How does this extract support cardiovascular wellness in supplements?

Standardised tanshinones, and in particular cryptotanshinone at levels ≥8%, are responsible for modulating nitric oxide synthase activity. This modulation has been observed to improve blood flow and endothelial function in human clinical studies that measure microcirculation parameters.

Q2. Can it be incorporated into acidic beverages without losing potency?

Yes, the extract maintains a solubility exceeding 98% in aqueous solutions with pH values ranging from 3.0 to 7.0. Colloidal stability is preserved under refrigerated conditions for periods longer than 12 months.

Q3. Is there evidence for skin benefits beyond antioxidant claims?

Research has demonstrated that cryptotanshinone reduces the expression of MMP-1 and inflammatory IL-6 markers. When the extract is formulated into serums at concentrations between 0.2% and 0.5%, a reduction in visible erythema has been documented in subjects with rosacea.

Related Information

Common Preparation Methods

The extract is produced by ethanol-water (70:30 v/v) extraction at 80°C for 3 hours using dried root fragments. This is followed by vacuum concentration at ≤50°C to preserve thermolabile tanshinones. The resultant concentrate is spray-dried using a maltodextrin carrier at a 1:2 ratio, with inlet and outlet temperatures of 160°C and 65°C respectively, yielding a powder with ≤5% moisture. Process controls include real-time HPLC monitoring for cryptotanshinone retention at ≥8%, verification of residual solvent levels (<100 ppm ethanol), and particle size optimisation (D90 <45µm) to ensure consistent dissolution. Final products are packaged under nitrogen with desiccant to guarantee a shelf-life of 24 months, and they meet specifications for heavy metals and microbial limits in nutraceutical applications.