HA6998 Arbutin/Bearberry Leaf Extract Powder

Arbutin/Bearberry Leaf Extract Powder Description

Arbutin/Bearberry Leaf Extract Powder appears as a fine white crystalline solid with a molecular formula of C₁₂H₁₆O₇ and a molecular weight of 272.25 g/mol. It is characterised by high solubility in dimethyl sulfoxide (≥13.7 mg/mL), water (≥18.7 mg/mL), and ethanol (≥8.3 mg/mL), though it forms colloidal suspensions in aqueous solutions due to polyphenol aggregation. The compound decomposes at temperatures exceeding 195°C but maintains stability below 60°C. Its efficacy is based on competitive inhibition of tyrosinase, with apparent inhibition constants (Kiapp) of 1.42 mM for monophenolase and 0.9 mM for diphenolase activities. Structurally, β-arbutin contains a hydroquinone moiety linked to a glucose unit, enabling penetration into basal keratinocytes to disrupt melanosome transfer without cytotoxicity. Stability requires pH 5–7 to prevent hydrolysis into hydroquinone, alongside protection from UV light and oxygen to avoid oxidation of phenolic rings. Analytical profiles confirm heavy metals ≤10 ppm, residual hydroquinone ≤20 ppm, and microbial limits compliant with pharmacopeial standards. Hygroscopicity necessitates airtight storage at 15–25°C with desiccants to ensure a 24-month shelf life.

Arbutin/Bearberry Leaf Extract Powder Applications

• Cosmetics and Skincare: Formulated into serums, creams, and spot correctors at 1%–7% concentrations to target hyperpigmentation, melasma, and post-inflammatory marks. β-Arbutin inhibits tyrosinase without photosensitivity risks, combining with niacinamide or vitamin C for enhanced brightening. Products include anti-ageing moisturisers, sunscreens with SPF boost, and acne scar treatments.
• Pharmaceuticals and Therapeutics: Utilised in topical dermatological preparations for burn recovery, reducing pain and inflammation while promoting scar-free healing. Oral formulations address urinary tract infections via hydroquinone release, functioning as an antimicrobial agent in bladder anti-infectives.
• Functional Food and Supplements: Integrated into oral beauty supplements for systemic antioxidant support. Combines with glutathione to inhibit intrinsic melanogenesis pathways, improving skin luminosity within 8–12 weeks of consistent use.
• Industrial and Research Applications: Employed as a stabiliser in colour-developing photographic solutions. In biomedical research, it serves as a control for tyrosinase inhibitors in studies of melanocyte behaviour and depigmentation drug efficacy.

Arbutin/Bearberry Leaf Extract Powder Packaging

Our products are packaged in customised cartons of various sizes based on the material dimensions. Small items are securely packed in PP boxes, while larger items are placed in custom wooden crates. We ensure strict adherence to packaging customisation and the use of appropriate cushioning materials to provide optimal protection during transportation.

Packaging: Carton, Wooden Box, or Customised.

Kindly review the packaging details provided for your reference.

Manufacturing Process

1.       Testing Method

(1)    Chemical Composition Analysis - Verified using techniques such as GDMS or XRF to ensure compliance with purity requirements.

(2)    Mechanical Properties Testing - Includes tensile strength, yield strength, and elongation tests to assess material performance.

(3)    Dimensional Inspection - Measures thickness, width, and length to ensure adherence to specified tolerances.

(4)    Surface Quality Inspection - Checks for defects such as scratches, cracks, or inclusions through visual and ultrasonic examination.

(5)    Hardness Testing - Determines material hardness to confirm uniformity and mechanical reliability.

Please refer to the SAM testing procedures for detailed information.

Arbutin/Bearberry Leaf Extract Powder FAQs

Q1. Will this lighten my entire face or just dark spots?

It selectively targets hyperpigmented areas by localising to melanin-rich zones. For overall brightening, pair with full-face products containing 2%–3% arbutin.

Q2. Can I use it with retinol or vitamin C?

Yes, but layer cautiously. Apply arbutin first, wait 10 minutes, then follow with low-concentration retinol (<0.3%) or stabilised vitamin C (L-ascorbic acid ≤10%). Avoid mixing in one formula to prevent pH conflicts.

Q3. Why did my dark spots temporarily darken?

Initial "purging" occurs as trapped melanin surfaces. This resolves within 2–3 weeks. Discontinue if persistent beyond 4 weeks or if irritation develops.

Related Information

1.       Common Preparation Methods

Arbutin/Bearberry Leaf Extract Powder is produced from sustainably harvested Arctostaphylos uva-ursi leaves, typically wildcrafted in Northern Europe or North America. Fresh leaves undergo washing with ozonated water, followed by shade-drying at ≤35°C to preserve thermolabile glycosides. Dried material is milled and subjected to ethanol-water extraction (40%–60% ethanol) at 50–55°C for 3–5 hours. The crude extract is filtered through activated carbon to remove pigments and tannins, then concentrated under vacuum at 45°C. Purification involves sequential crystallisation using acetone-water solvents and macroporous resin chromatography (D101 resin) to isolate β-arbutin isomers. The crystallised arbutin is washed with ethyl acetate, dried under inert gas, and micronised to a particle size of ≤80 mesh. Final powder is standardised to ≥98% β-arbutin via HPLC, with quality control testing for residual solvents (ethanol ≤5 000 ppm), heavy metals (Pb ≤10 ppm), and microbial contaminants to meet ISO 22716 cosmetic GMP standards.