HA9003 Luteolin Powder

Luteolin Powder Description

Luteolin Powder is characterised as a light yellow crystalline solid with a molecular weight of 286.24 g/mol and a melting point exceeding 330°C. It displays low intrinsic solubility in water (1.01 μg·mL⁻¹) but moderate solubility in dimethyl sulfoxide (14.31 mg·mL⁻¹) and alkaline solutions. The compound decomposes under prolonged UV exposure or temperatures beyond 60°C, requiring storage in airtight, light-shielded containers at 4°C. Its bioactivity arises from a polyhydroxyflavone structure that enables effective free-radical scavenging, with singlet oxygen quenching efficiency exceeding that of synthetic antioxidants. Pharmacologically, luteolin competitively inhibits tyrosinase and binds to the SARS-CoV-2 main protease (Kd = 8.2 μM), disrupting viral replication. Stability is pH-dependent, showing optimal integrity at pH 5–7 but degradation in strongly acidic or alkaline conditions due to glycosidic bond hydrolysis. Analytical profiles confirm heavy metals ≤10 ppm and microbial contaminants controlled to pharmacopeial limits. Advanced formulations such as cyclodextrin complexes or solid dispersions enhance aqueous solubility by 100 times through hydrogen bonding and conversion to an amorphous state, although hygroscopicity necessitates desiccated storage to prevent aggregation.

Luteolin Powder Applications

• Pharmaceuticals and Therapeutics: Formulated into capsules and tablets for anti-inflammatory and anticancer therapies. Luteolin inhibits NF-κB and COX-2 pathways, reducing TNF-α production by 70% in lung carcinoma models and improving severe acute pancreatitis via HO-1 upregulation. Solid dispersions with PVP/VA augment oral bioavailability to 348%, facilitating clinical application in neurology and oncology.
• Nutraceuticals and Functional Foods: Incorporated into supplements for neuroprotection and liver health. Doses of 100 mg/kg upregulate glutathione synthesis, mitigating non-alcoholic steatohepatitis in metabolic syndrome models. Combining with curcumin yields antioxidant effects in functional beverages.
• Cosmetics and Personal Care: Integrated into anti-aging serums (0.5%–5%) for UV protection. Luteolin reduces collagenase activity by 40% and inhibits melanogenesis via tyrosinase suppression, targeting hyperpigmentation and photoaging in sensitive skin formulations.
• Biomedical Research and Diagnostics: Utilised as a molecular probe tagged with biotin for cellular imaging. Targets avidin receptors to visualise cancer cell surfaces and study flavonoid uptake kinetics. Also explored for COVID-19 therapeutics through binding to SARS-CoV-2 main protease.
• Agriculture and Food Preservation: Applied as a natural preservative in active packaging films. Extends meat shelf life by 17.8% through lipid peroxidation inhibition and curtails fungal growth in postharvest crops.

Luteolin Powder Packaging

Our products are packaged in customised cartons of various sizes based on the material dimensions. Smaller items are securely packed in PP boxes, while larger items are placed in custom wooden crates. We ensure strict adherence to packaging customisation and utilise appropriate cushioning materials to provide optimal protection during transportation.

Packaging: Carton, Wooden Box, or Customised.

Kindly review the packaging details provided for your reference.

Manufacturing Process

1.       Testing Method

(1)    Chemical Composition Analysis - Verified using techniques such as GDMS or XRF to ensure compliance with purity requirements.

(2)    Mechanical Properties Testing - Includes tensile strength, yield strength, and elongation tests to assess material performance.

(3)    Dimensional Inspection - Measures thickness, width, and length to ensure adherence to specified tolerances.

(4)    Surface Quality Inspection - Checks for defects such as scratches, cracks, or inclusions through visual and ultrasonic examination.

(5)    Hardness Testing - Determines material hardness to confirm uniformity and mechanical reliability.

Please refer to the SAM testing procedures for detailed information.

Luteolin Powder FAQs

Q1. How to improve its absorption?

Select PVP/VA-based solid dispersions—bioavailability increases by 3.5 times compared to raw powder. Avoid high-fat meals to prevent lymphatic uptake delays.

Q2. Does it expire? How to store?

Shelf life: 2 years unopened. Store at 4°C in dark glass vials with desiccants. Discard if the colour darkens to brown.

Q3. Can I apply it topically for acne?

Yes. Serums with 2% concentration reduce pustules by 60% via IL-6 suppression. Conduct a patch test first—avoid if allergic to Asteraceae plants.

Related Information

1.       Common Preparation Methods

Luteolin Powder is extracted from peanut hulls or celery through ethanol-water (40%–60%) at 50°C for 4 hours, followed by filtration and vacuum concentration. The crude extract undergoes purification via silica gel chromatography, eluting with ethyl acetate to isolate luteolin fractions. To enhance solubility, the compound is complexed with carriers using two advanced methods: solvent-based solid dispersion combines luteolin and PVP/VA (1:11 ratio) in ethanol at 60°C, evaporated to form amorphous solids; alternatively, β-cyclodextrin inclusion involves mixing luteolin with hydroxypropyl-β-cyclodextrin (1:5 molar ratio) in water under high-pressure homogenisation. Both products are spray-dried below 60°C to yield powders with a standardisation of ≥98% purity. Quality control includes HPLC validation, residual solvent testing, and microbial screening per pharmacopeial standards.