Chromium oligopeptide activates insulin receptor tyrosine kinase activity.

Title	Chromium oligopeptide activates insulin receptor tyrosine kinase activity.
Authors	C. M. Davis, J. B. Vincent
Magazine	Biochemistry
Date	04/15/1997
DOI	10.1021/bi963154t
Introduction	This study presents a novel mechanism for enhancing insulin receptor tyrosine kinase activity following insulin exposure. The chromium-containing oligopeptide, known as low molecular weight chromium-binding substance (LMWCr), exhibits no impact on the tyrosine protein kinase activity of rat adipocytic membrane fragments when insulin is absent. However, in the presence of insulin, this oligopeptide significantly elevates insulin-stimulated kinase activity in these membrane fragments by up to 8-fold. Investigations using isolated rat insulin receptor confirm that LMWCr binds to the insulin-activated receptor with a dissociation constant of approximately 250 pM, leading to an increase in its tyrosine protein kinase activity. The stimulatory effect of LMWCr on insulin receptor tyrosine kinase activity is directly linked to its chromium composition. These findings offer clarification for the previously unclear connection between chromium, adult-onset diabetes, and cardiovascular disease.
Quote	C M Davis and J B Vincent. Chromium oligopeptide activates insulin receptor tyrosine kinase activity.. Biochemistry. 1997. Vol. 36(15). DOI: 10.1021/bi963154t
Element	Chromium (Cr)
Industry	Pharmaceutical Industry