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  • Bioorthogonal Catalytic Activation of Platinum and Ruthenium Anticancer Complexes by FAD and Flavoproteins

    • Bioorthogonal Catalytic Activation of Platinum and Ruthenium Anticancer Complexes by FAD and Flavoproteins

    Title Bioorthogonal Catalytic Activation of Platinum and Ruthenium Anticancer Complexes by FAD and Flavoproteins
    Authors Silvia Alonso‐de Castro, Aitziber L. Cortajarena, Fernando López‐Gallego, Luca Salassa
    Magazine Angewandte Chemie (International Ed. in English)
    Date 02/15/2018
    DOI https://doi.org/10.1002/anie.201800288
    Introduction Recent progress in bioorthogonal catalysis introduces innovative chemical methodologies for achieving chemoselective reactions within intricate biological systems. This study unveils the role of FAD (flavin adenine dinucleotide), FMN (flavin mononucleotide), and an array of flavoproteins as atypical photocatalysts that effectively transform Pt IV and Ru II complexes into potentially harmful Pt II or Ru II−OH 2 compounds. With the aid of electron donors and minimal visible light exposure, flavoproteins such as mini singlet oxygen generator (miniSOG) and NADH oxidase (NOX) enable bioorthogonal activation of Pt IV prodrugs. Furthermore, NOX demonstrates Pt IV activation in the absence of light when NADH is present, marking the first recognition of flavoenzymes potentially initiating the activity of Pt IV-based chemotherapeutic drugs.
    Quote Silvia Alonso‐de Castro, Aitziber L Cortajarena and Fernando Lopez‐Gallego et al. Bioorthogonal Catalytic Activation of Platinum and Ruthenium Anticancer Complexes by FAD and Flavoproteins. Angew. Chem. Int. Ed. Engl. 2018. DOI: 10.1002/anie.201800288
    Element Platinum (Pt) , Ruthenium (Ru)
    Materials Chemical Compounds
    Industry Pharmaceutical Industry
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