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Efficacy, Safety, and Patient Reported Outcomes of Rhenium-Skin Cancer Therapy for Non-Melanoma Skin Cancer: 1-Year Results from the EPIC-Skin Study

Title	Efficacy, Safety, and Patient Reported Outcomes of Rhenium-Skin Cancer Therapy for Non-Melanoma Skin Cancer: 1-Year Results from the EPIC-Skin Study
Authors	Giuseppe Cardaci, Siddhartha Baxi, Saima Vohra, Cody Allison, Angela Hong, Nicola Mulholland, Mike Sathekge, Kgomotso Mokoala, Martin Heuschkel, Julia Tietze, Siroos Mirzaei, Gerhard Dahlhoff
Magazine	Advances in Radiation Oncology
Date	04/29/2025
DOI	10.1016/j.adro.2025.101802
Introduction	Rhenium skin cancer therapy (SCT) represents a novel, non-invasive treatment approach for non-melanoma skin cancer (NMSC), delivered in a single outpatient session. A global, multicentre phase 4 clinical study evaluates the efficacy, safety, cosmesis, and patient-reported outcomes of OncoBeta rhenium-SCT for NMSC. The 12-month interim results include findings on toxicity, cosmetic outcomes, and patient feedback. Rhenium-SCT is applied as a resin on adhesive foil to lesions, with a 50 Gy dose to the deepest point. Effectiveness is measured using modified Response Evaluation Criteria in Solid Tumours, with primary endpoint data planned for 24 months. Secondary endpoints focus on quality of life and cosmesis. Results indicate a 94.1% complete response rate, with favourable safety and patient satisfaction metrics, underscoring its viability as an alternative to surgical interventions.
Quote	Giuseppe Cardaci, Siddhartha Baxi and Saima Vohra et al. Efficacy, Safety, and Patient Reported Outcomes of Rhenium-Skin Cancer Therapy for Non-Melanoma Skin Cancer: 1-Year Results from the EPIC-Skin Study. Advances in Radiation Oncology. 2025. Vol. 10(7). DOI: 10.1016/j.adro.2025.101802
Industry	Pharmaceuticals & Cosmetics

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