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  • LMD-13. ReSPECT-LM: Maximum tolerated dose, safety, and efficacy of intraventricular Rhenium-186 Nanoliposome (186RNL) for leptomeningeal metastases

    • LMD-13. ReSPECT-LM: Maximum tolerated dose, safety, and efficacy of intraventricular Rhenium-186 Nanoliposome (186RNL) for leptomeningeal metastases

    Title LMD-13. ReSPECT-LM: Maximum tolerated dose, safety, and efficacy of intraventricular Rhenium-186 Nanoliposome (186RNL) for leptomeningeal metastases
    Authors Andrew Brenner, John Floyd, Ande Bao, William Phillips, Gregory Stein
    Magazine Neuro-oncology Advances
    Date 08/09/2021
    DOI 10.1093/noajnl/vdab071.038
    Introduction Leptomeningeal metastases (LM) are a severe complication of advanced cancer affecting the central nervous system. Novel approaches are essential to enhance survival and quality of life. Rhenium-186 NanoLiposome (186RNL) enables targeted delivery of beta-emitting radiation to tumours. In a Phase 1 trial with recurrent glioblastoma patients, the mean absorbed dose for 75% tumour coverage was 392 Gy. The treatment showed tolerable adverse effects, with cerebral oedema resolving post-steroid treatment. This two-part Phase 1 study aims to determine the safety and maximum tolerated dose of 186RNL in LM patients, followed by efficacy assessment in breast and lung cancer cohorts. The primary focus is on anti-tumour activity, with secondary endpoints evaluating pharmacokinetics, dosimetry, and survival rates. Enrollment is set to commence in the second half of 2021.
    Quote Andrew Brenner, John Floyd and Ande Bao et al. LMD-13. ReSPECT-LM: Maximum tolerated dose, safety, and efficacy of intraventricular Rhenium-186 Nanoliposome (186RNL) for leptomeningeal metastases. Neuro-oncology Advances. 2021. Vol. 3(Suppl 3):iii10-iii10. DOI: 10.1093/noajnl/vdab071.038
    Materials Nanocomposites
    Industry Pharmaceutical Industry
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