{{flagHref}}

Products

Products
Categories
Blog
Podcast
Application
Document

|

|

/ {{languageFlag}}

Inquiry

Please start talking

a

On-Surface Azide–Alkyne Cycloaddition Reaction: Does It Click with Ruthenium Catalysts?

Title	On-Surface Azide–Alkyne Cycloaddition Reaction: Does It Click with Ruthenium Catalysts?
Authors	Tiexin Li, Essam M. Dief, Zlatica Kalužná, Melanie MacGregor, Cina Foroutan-Nejad, Nadim Darwish
Magazine	Langmuir
Date	04/26/2022
DOI	10.1021/acs.langmuir.2c00100
Introduction	The 'click' azide-alkyne reaction is a popular method in various fields due to its simplicity, selectivity, and high yield, with copper(I) catalysts typically facilitating the formation of 1,4-disubstituted 1,2,3-triazole regioisomers. However, ruthenium-based catalysts have been developed to produce the 1,5-disubstituted isomer selectively. While ruthenium catalysis has been explored in solution, its efficacy for surface-based reactions remains uncertain, as do the electrical properties of the resulting isomers. In this study, we explore ruthenium catalysts for surface azide-alkyne reactions, aiming to produce 1,5-disubstituted triazoles and comparing their electrochemical properties with the copper-catalysed 1,4-isomer. Our findings reveal that ruthenium(II) complexes do catalyse surface reactions, but at a slower rate than copper, due to the size of the catalyst. The electron transfer rate constant for ruthenium is 30% that of copper, and the lower conductivity of the 1,5-isomer is supported by nonequilibrium Green's function computations. These results indicate the potential of ruthenium catalysis for surface reactions and suggest an electrical approach for distinguishing click reaction isomers.
Quote	Tiexin Li, Essam M. Dief and Zlatica Kalužná et al. On-Surface Azide–Alkyne Cycloaddition Reaction: Does It Click with Ruthenium Catalysts?. Langmuir. 2022. Vol. 38(18):5532-5541. DOI: 10.1021/acs.langmuir.2c00100
Element	Copper (Cu) , Ruthenium (Ru)
Materials	Chemical Compounds
Industry	Chemical & Pharmacy , Research & Laboratory

Related papers

Loading... Please wait...

Publish your research and articles on the SAM website

Disclaimer

This site only provides metadata for academic works to enable users to easily find relevant information. For full access to the works, please use the DOI to visit the original publisher's website. The data comes from publicly accessible scientific databases and complies with the terms of use of these platforms. If you have any concerns regarding copyright, please contact us. We will address them immediately.

Success! You are now subscribed.

You have successfully subscribed! Check your inbox soon to receive great emails from this sender.

Copyright © 1994-2025 Stanford Advanced Materials owned by Oceania International LLC, all rights reserved