Photoactivatable Ruthenium Complexes Containing Minimal Straining Benzothiazolyl-1,2,3-triazole Chelators for Cancer Treatment

Title	Photoactivatable Ruthenium Complexes Containing Minimal Straining Benzothiazolyl-1,2,3-triazole Chelators for Cancer Treatment
Authors	Francisco J. Ballester, Alba Hernández-García, M. Dolores Santana, Delia Bautista, Pezhman Ashoo, Enrique Ortega-Forte, Giampaolo Barone, José Ruiz
Magazine	Inorganic Chemistry
Date	02/22/2024
DOI	10.1021/acs.inorgchem.3c04432
Introduction	Tailored ruthenium sandwich complexes featuring photoresponsive arene ligands efficiently catalyse azide-thioalkyne cycloaddition when exposed to UV light. These reactions can be executed in a bioorthogonal manner within aqueous environments containing biological components. The approach is applicable for selectively modifying biopolymers, such as DNA or peptides. Notably, this ruthenium-based method and the traditional copper-catalysed azide-alkyne cycloaddition are both compatible and mutually orthogonal.
Quote	Francisco J. Ballester, Alba Hernández-García and M. Dolores Santana et al. Photoactivatable Ruthenium Complexes Containing Minimal Straining Benzothiazolyl-1,2,3-triazole Chelators for Cancer Treatment. Inorganic Chemistry. 2024. Vol. 63(14):6202-6216. DOI: 10.1021/acs.inorgchem.3c04432
Element	Ruthenium (Ru)
Materials	Chemical Compounds , Biopolymers
Industry	Pharmaceutical Industry , Research & Laboratory

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