Piano-Stool Ruthenium(II) Complexes with Delayed Cytotoxic Activity: Origin of the Lag Time

Title	Piano-Stool Ruthenium(II) Complexes with Delayed Cytotoxic Activity: Origin of the Lag Time
Authors	Laia Rafols, Dana Josa, David Aguilà, Leoní A. Barrios, Olivier Roubeau, Jordi Cirera, Vanessa Soto-Cerrato, Ricardo Pérez-Tomás, Manuel Martínez, Arnald Grabulosa, Patrick Gamez
Magazine	Inorganic Chemistry
Date	05/12/2021
DOI	10.1021/acs.inorgchem.1c00507
Introduction	In this study, new piano-stool ruthenium(II) complexes were synthesised to assess steric hindrance effects of bulky phosphane ligands on halide exchange reactions. Using η6-arene rings such as methyl benzoate and p-cymene, four complexes were created, but they exhibited poor cytotoxicity initially. However, aged DMSO solutions of one complex demonstrated improved activity over time. This led to the discovery that certain complexes transform in DMSO to cyclometalated species, enhancing cytotoxicity. Cyclometalated complexes were synthesised and tested, showing greater activity compared to non-cyclometalated counterparts.
Quote	Laia Rafols, Dana Josa and David Aguilà et al. Piano-Stool Ruthenium(II) Complexes with Delayed Cytotoxic Activity: Origin of the Lag Time. Inorganic Chemistry. 2021. Vol. 60(11):7974-7990. DOI: 10.1021/acs.inorgchem.1c00507
Element	Iodine (I) , Ruthenium (Ru)
Materials	Chemical Compounds
Industry	Chemical & Pharmacy

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