Protoporphyrin IX-Derived Ruthenium(II) Complexes for Photodynamic Therapy in Gastric Cancer Cells

Title	Protoporphyrin IX-Derived Ruthenium(II) Complexes for Photodynamic Therapy in Gastric Cancer Cells
Authors	Andrés Restrepo-Acevedo, María Isabel Murillo, Christophe Orvain, Chloé Thibaudeau, Sevda Recberlik, Lucas Verget, Virginia Gómez Vidales, Christian Gaiddon, Georg Mellitzer, Ronan Le Lagadec
Magazine	Inorganic Chemistry
Date	05/02/2025
DOI	10.1021/acs.inorgchem.5c00896
Introduction	Tetrapyrrole-ruthenium(II) compounds serve as effective photosensitisers for photodynamic therapy (PDT) in gastric cancer cells. These complexes exhibit minimal dark toxicity but show significant cytotoxicity when exposed to light. They can generate singlet oxygen and superoxide radicals, even in low oxygen environments. The induced cell death occurs through a caspase 3-mediated apoptotic pathway and involves CHOP, an endoplasmic reticulum stress transcription factor, potentially reducing susceptibility to drug-resistance mechanisms.
Quote	Andrés Restrepo-Acevedo, María Isabel Murillo and Christophe Orvain et al. Protoporphyrin IX-Derived Ruthenium(II) Complexes for Photodynamic Therapy in Gastric Cancer Cells. Inorganic Chemistry. 2025. Vol. 64(19):9684-9702. DOI: 10.1021/acs.inorgchem.5c00896
Element	Oxygen (O) , Ruthenium (Ru)
Industry	Chemical & Pharmacy

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