Ruthenium-Mediated N‑Arylation for DNA-Encoded Libraries

Title	Ruthenium-Mediated N‑Arylation for DNA-Encoded Libraries
Authors	Suraj Kanoo, Eduardo de Pedro Beato, Tim Schulte, Lara Vogelsang, Luca Torkowski, Felix Waldbach, Philipp Hartmann, Riya Kayal, Karl-Josef Dietz, Tobias Ritter
Magazine	Journal of the American Chemical Society
Date	09/11/2025
DOI	https://doi.org/10.1021/jacs.5c11842
Introduction	C–N cross coupling reactions are essential for forming carbon–nitrogen bonds, but achieving chemoselectivity with amino functionalities in oligonucleotides remains challenging. This study introduces a novel ruthenium reagent that facilitates selective N-arylation of amine–DNA conjugates, differing from traditional palladium-based catalysts. The reagent uses η6 π-arene coordination to activate haloarenes in situ for subsequent S NAr with the amine. It is compatible with various haloarenes and aliphatic amines, operating under mild conditions.
Quote	Suraj Kanoo, Eduardo de Pedro Beato and Tim Schulte et al. Ruthenium-Mediated N‑Arylation for DNA-Encoded Libraries. J. Am. Chem. Soc. 2025. Vol. 147(38):35011-35018. DOI: 10.1021/jacs.5c11842
Element	Ruthenium (Ru)
Materials	Chemical Compounds
Industry	Chemical & Pharmacy , Research & Laboratory

You have successfully subscribed! Check your inbox soon to receive great emails from this sender.

NEED HELP?