Ruthenium Polypyridyl Complex Bound to a Unimolecular Chair-Form G-Quadruplex

Title	Ruthenium Polypyridyl Complex Bound to a Unimolecular Chair-Form G-Quadruplex
Authors	Kane T. McQuaid, Shuntaro Takahashi, Lena Baumgaertner, David J. Cardin, Neil G. Paterson, James P. Hall, Naoki Sugimoto, Christine J. Cardin
Magazine	Journal of the American Chemical Society
Date	03/24/2022
DOI	10.1021/jacs.2c00178
Introduction	The DNA G-quadruplex is recognised for its diverse topologies and transient nature within live cells. Stabilisation of a specific topology by small molecules is crucial for therapeutic use. This study reveals the enantiospecific binding of the ruthenium complex Λ-[Ru(phen)2(qdppz)]2+ to a modified human telomeric G-quadruplex sequence in an antiparallel chair form. This unique interaction involves an intercalation cavity formed by terminal G-quartet and central narrow lateral loop, with wide lateral loops connected by a K+ ion, coordinating thymine residues. The complex exhibited potent replication inhibition in both native and modified telomeric sequences, as shown in a Klenow fragment assay.
Quote	Kane T. McQuaid, Shuntaro Takahashi and Lena Baumgaertner et al. Ruthenium Polypyridyl Complex Bound to a Unimolecular Chair-Form G-Quadruplex. J. Am. Chem. Soc. 2022. Vol. 144(13):5956-5964. DOI: 10.1021/jacs.2c00178
Element	Ruthenium (Ru)
Materials	Chemical Compounds
Industry	Pharmaceutical Industry

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