Ruthenium‐Catalysed C−H Arylation of Benzoic Acids and Indole Carboxylic Acids with Aryl Halides

Title	Ruthenium‐Catalysed C−H Arylation of Benzoic Acids and Indole Carboxylic Acids with Aryl Halides
Authors	Dr. Marco Simonetti, Diego M. Cannas, Adyasha Panigrahi, Dr. Szymon Kujawa, Dr. Michal Kryjewski, Dr. Pan Xie, Prof. Igor Larrosa
Magazine	Chemistry (Weinheim an Der Bergstrasse, Germany)
Date	12/05/2016
DOI	10.1002/chem.201605068
Introduction	This study presents the first Ru-catalysed C−H arylation of benzoic acids using readily available aryl (pseudo)halides. Notably, the reaction proceeds without silver salt additives and facilitates the arylation of hindered benzoic acids, as well as ortho-substituted halorarenes that are typically unreactive. Additionally, this method is applicable to indole carboxylic acids, enabling access to C7‐, C6‐, C5‐, and C4‐arylated indole compounds, diverging from the traditional reactivity at the C2 and C3 positions of indole.
Quote	Marco Simonetti, Diego M. Cannas and Adyasha Panigrahi et al. Ruthenium-Catalysed C−H Arylation of Benzoic Acids and Indole Carboxylic Acids with Aryl Halides. Chemistry. 2016. DOI: 10.1002/chem.201605068
Element	Ruthenium (Ru)
Materials	Chemical Compounds
Industry	Chemical & Pharmacy

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