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  • Ruthenium(II) Polypyridyl Complexes and Metronidazole Derivatives: A Powerful Combination in the Design of Photoresponsive Antibacterial Agents Effective under Hypoxic Conditions

    • Ruthenium(II) Polypyridyl Complexes and Metronidazole Derivatives: A Powerful Combination in the Design of Photoresponsive Antibacterial Agents Effective under Hypoxic Conditions

    Title Ruthenium(II) Polypyridyl Complexes and Metronidazole Derivatives: A Powerful Combination in the Design of Photoresponsive Antibacterial Agents Effective under Hypoxic Conditions
    Authors Gina Elena Giacomazzo, Luca Conti, Camilla Fagorzi, Marco Pagliai, Claudia Andreini, Annalisa Guerri, Brunella Perito, Alessio Mengoni, Barbara Valtancoli, Claudia Giorgi
    Magazine Inorganic Chemistry
    Date 05/10/2023
    DOI 10.1021/acs.inorgchem.3c00214
    Introduction Ruthenium(II) polypyridyl complexes (RPCs) offer new possibilities in photoactivated chemotherapy (PACT) by enabling drug activation with light while circumventing the need for molecular oxygen, contrary to traditional photodynamic therapy. This study introduces MTZH-1 and MTZH-2, metronidazole analogues incorporated into strained ruthenium complexes, demonstrating increased antibacterial efficacy under hypoxic conditions against Bacillus subtilis, a Gram-positive bacteria model. The photoreleased 5-nitroimidazole-based ligands from these complexes show high potency, rivaling clinical metronidazole. The MTZ derivatives' chemical structure reduces interaction with NimA reductases, indicating potential in addressing antimicrobial resistance. This research marks a significant advance in developing photoresponsive tools for infectious disease management under hypoxic conditions.
    Quote Giacomazzo, G.E.; Conti, L.; Fagorzi, C.; Pagliai, M.; Andreini, C.; Guerri, A.; Perito, B.; Mengoni, A.; Valtancoli, B.; Giorgi, C. Ruthenium(II) Polypyridyl Complexes and Metronidazole Derivatives: A Significant Combination in the Design of Photoresponsive Antibacterial Agents Effective under Hypoxic Conditions. 2023. DOI: 10.1021/acs.inorgchem.3c00214
    Element Ruthenium (Ru)
    Industry Pharmaceutical Industry
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