{{flagHref}}

Products

Products
Categories
Blog
Podcast
Application
Document

|

|

/ {{languageFlag}}

Inquiry

Please start talking

a

Ruthenium(II) Polypyridyl Complexes Containing COUBPY Ligands as Potent Photosensitizers for the Efficient Phototherapy of Hypoxic Tumours

Title	Ruthenium(II) Polypyridyl Complexes Containing COUBPY Ligands as Potent Photosensitizers for the Efficient Phototherapy of Hypoxic Tumours
Authors	Diego Abad-Montero, Albert Gandioso, Eduardo Izquierdo-García et al.
Magazine	Journal of the American Chemical Society
Date	02/15/2025
DOI	10.1021/jacs.4c15036
Introduction	Hypoxia, a common trait in many solid tumours, contributes to cancer aggression, metastasis, and resistance to standard treatments, leading to poor patient outcomes. Photodynamic therapy (PDT) effectiveness is challenged by hypoxia, as it depends on generating cytotoxic reactive oxygen species (ROS) through photosensitiser (PS) irradiation, a process partially reliant on oxygen levels. This study presents a new series of effective PSs based on ruthenium(II) polypyridyl complexes with COUBPY ligands. These complexes demonstrate significant in vitro cytotoxicity against CT-26 cancer cells under light irradiation and are potent in both normoxic and hypoxic conditions, while remaining non-toxic without light exposure. The lead compound, SCV49, exhibits promising pharmacokinetics, excellent toxicity tolerance, and strong tumour growth inhibition in mice with CT-26 tumours when irradiated with deep-red light (660 nm) at low doses. These findings suggest SCV49 as a promising candidate for further preclinical development, particularly targeting large hypoxic solid tumours.
Quote	Diego Abad-Montero, Albert Gandioso and Eduardo Izquierdo-García et al. Ruthenium(II) Polypyridyl Complexes Containing COUBPY Ligands as Potent Photosensitisers for the Efficient Phototherapy of Hypoxic Tumours. J. Am. Chem. Soc. 2025. Vol. 147(9):7360-7376. DOI: 10.1021/jacs.4c15036

Related papers

Loading... Please wait...

Publish your research and articles on the SAM website

Disclaimer

This site only provides metadata for academic works to enable users to easily find relevant information. For full access to the works, please use the DOI to visit the original publisher's website. The data comes from publicly accessible scientific databases and complies with the terms of use of these platforms. If you have any concerns regarding copyright, please contact us. We will address them immediately.

Success! You are now subscribed.

You have successfully subscribed! Check your inbox soon to receive great emails from this sender.

Copyright © 1994-2025 Stanford Advanced Materials owned by Oceania International LLC, all rights reserved