Shift of cell-death mechanisms in primary human neutrophils with a ruthenium photosensitiser

Title	Shift of cell-death mechanisms in primary human neutrophils with a ruthenium photosensitiser
Authors	Nicolás Montesdeoca, Jennifer M. Mohr, Sebastian Kruss, Johannes Karges
Magazine	Journal of Biological Inorganic Chemistry
Date	12/14/2024
DOI	10.1007/s00775-024-02088-4
Introduction	Primary human neutrophils are essential for innate immunity, as they respond to inflammation guided by chemotactic gradients. They can undergo apoptosis or NETosis, a form of cell death that releases extracellular traps to combat pathogens. This study investigates a ruthenium complex as a photosensitiser, generating reactive oxygen species (ROS) in neutrophils, remaining non-toxic in the dark but becoming cytotoxic under blue light. The complex shifts neutrophil death from NETosis to apoptosis, with ROS levels determining the death mechanism. Controlling this balance could assist in managing infectious diseases.
Quote	Nicolás Montesdeoca, Jennifer M. Mohr and Sebastian Kruss et al. Shift of cell-death mechanisms in primary human neutrophils with a ruthenium photosensitiser. 2024. DOI: 10.1007/s00775-024-02088-4
Element	Ruthenium (Ru)
Industry	Pharmaceutical Industry

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