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Synthesis, structural characterisation and study of antioxidant and anti-PrP Sc properties of flavonoids and their rhenium(I)–tricarbonyl complexes

Title	Synthesis, structural characterisation and study of antioxidant and anti-PrP Sc properties of flavonoids and their rhenium(I)–tricarbonyl complexes
Authors	Pigi Glykofridi, Vassiliki-Eleni Tziouri, Konstantinos Xanthopoulos, Maria-Eirini Vlachou, Susana Correia, Anna-Lisa Fischer, Katrin Thüne, Antonios Hatzidimitriou, Inga Zerr, Matthias Schmitz, Theodoros Sklaviadis, Dimitra Hadjipavlou-Litina, Dionysia Papagiannopoulou
Magazine	Journal of Biological Inorganic Chemistry
Date	01/25/2023
DOI	10.1007/s00775-022-01986-9
Introduction	This research focuses on synthesising and evaluating new rhenium–tricarbonyl complexes formed with flavonoids such as quercetin, resokaempferol, chrysin, and naringenin. These complexes are analysed for their neuroprotective and anti-PrP properties. Resokaempferol is synthesised from 2,2',4-trihydroxychalcone using H2O2/NaOH. The synthesis of rhenium–tricarbonyl complexes involves reacting fac-[Re(CO)3(sol)3]+ with flavonoids in methanol or water. These complexes are purified through semi-preparative HPLC and characterised spectroscopically. Re-chrysin's structure is determined by X-ray crystallography. The antioxidant properties, lipid peroxidation inhibition, and lipoxygenase inhibition are assessed in vitro. The flavonoids and their complexes are tested for inhibiting the formation and aggregation of PrP Sc using a real-time quaking-induced conversion assay, showing all compounds prevent abnormal PrP formation and aggregation.
Quote	Pigi Glykofridi, Vassiliki-Eleni Tziouri and Konstantinos Xanthopoulos et al. Synthesis, structural characterisation and study of antioxidant and anti-PrP <sup>Sc</sup> properties of flavonoids and their rhenium(I)–tricarbonyl complexes. 2023. DOI: 10.1007/s00775-022-01986-9
Materials	Chemical Compounds
Topics	Biomedical Materials
Industry	Pharmaceutical Industry

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