Unexpected Latency of Z-Stereoretentive Ruthenium Olefin Metathesis Catalysts Bearing Unsymmetrical N-heterocyclic Carbene or Cyclic(alkyl)(amino)carbene Ligands

Title	Unexpected Latency of Z-Stereoretentive Ruthenium Olefin Metathesis Catalysts Bearing Unsymmetrical N-heterocyclic Carbene or Cyclic(alkyl)(amino)carbene Ligands
Authors	Łukasz Grzesiński, Mariusz Milewski, Maryana Nadirova, Anna Kajetanowicz, Karol Grela
Magazine	Organometallics
Date	11/02/2022
DOI	10.1021/acs.organomet.2c00428
Introduction	A series of ruthenium complexes with CAAC or uNHC ligands and a dithiocatechol fragment were synthesised and analysed spectroscopically. Their activity and Z-selectivity were evaluated in various olefin metathesis reactions. Notably, unlike NHC-bearing catalysts Ru4a and Ru4b, the CAAC and uNHC counterparts exhibited minimal activity. Despite this, Ru8 facilitated the formation of a 16-membered macrocyclic lactone with a musk scent and excellent chemoselectivity, without C–C double-bond migration, even at concentrations 40 times typical for such macrocyclisations. However, the conversion rates remained low.
Quote	Łukasz Grzesiński, Mariusz Milewski and Maryana A. Nadirova et al. Unexpected Latency of <i>Z</i>-Stereoretentive Ruthenium Olefin Metathesis Catalysts Bearing Unsymmetrical N-heterocyclic Carbene or Cyclic(alkyl)(amino)carbene Ligands. Organometallics. 2022. DOI: 10.1021/acs.organomet.2c00428
Element	Ruthenium (Ru)

You have successfully subscribed! Check your inbox soon to receive great emails from this sender.

NEED HELP?