BP10981 OH-PDLA-COOH, Low Molecular Weight Grades, IV ≤ 1 dl/g, Mw ≤ 90 kDa

OH-PDLA-COOH, Low Molecular Weight Grades, IV ≤ 1 dl/g, Mw ≤ 90 kDa Description

OH-PDLA-COOH (Low Mw Grade) is an asymmetrically end-functionalised poly(D-lactic acid) in powder form, with a molecular weight ≤ 90 kDa and intrinsic viscosity ≤ 1 dl/g. It features a hydroxyl group at one terminus and a carboxyl group at the other, providing two distinct pathways for chemical modification and conjugation. The D-configured backbone adds the capability for stereocomplexation. This combination of asymmetric reactivity and stereoregularity makes it a valuable tool for synthesising sophisticated polymer architectures, bio-conjugates, and functional materials with tailored interfaces and degradation profiles.

OH-PDLA-COOH, Low Molecular Weight Grades, IV ≤ 1 dl/g, Mw ≤ 90 kDa Applications

1.         Polymer Synthesis & Bioconjugation
   - Heterotelechelic Building Block: Used for the sequential synthesis of A-B type block copolymers or for creating polymers with site-specific functionalisation.
   - Drug-Polymer Conjugate Precursor: The carboxyl group allows direct conjugation of amine-containing drugs or targeting ligands, while the hydroxyl group can be used for further PEGylation or solubility modification.

2.        Functional Coatings & Surface Engineering
   - Reactive Coating Agent: Applied as a thin film on implants or sensors, where the carboxyl group enables covalent immobilisation of biomolecules (e.g., RGD peptides) to enhance cell adhesion or biospecificity.
   - Interface Modifier in Composites: Used to improve the interfacial adhesion between PDLA-based matrices and other materials (e.g., hydroxyapatite in bone composites) through its dual reactive ends.

3.        Electronics & Biomedical Devices
   - Degradable Encapsulant/Dielectric Layer: Used in transient electronics as a degradable insulating layer, with the end groups allowing for tuning of adhesion and degradation rates.
   - Matrix for pH-Responsive Delivery: Utilised in drug delivery systems where the carboxyl group can provide pH-dependent release behaviour or enable the formation of ionic complexes.

OH-PDLA-COOH, Low Molecular Weight Grades, IV ≤ 1 dl/g, Mw ≤ 90 kDa Packing

The product is supplied in vacuum-sealed, moisture-proof packaging with desiccant to ensure stability during transportation and storage. We offer flexible packaging sizes tailored to customer requirements from R&D to production scale.

Additional Information

Hydroxy-carboxyl heterotelechelic low molecular weight PDLA represents a versatile class of polymers where end-group asymmetry is a design feature. This specific functionality enables synthetic routes and material properties that are difficult to achieve with symmetrically terminated polymers.

Stanford Advanced Materials (SAM) focuses on the precise synthesis of such structurally defined polymers, ensuring high fidelity of both end groups and controlled molecular weight. This enables researchers and formulators to leverage the unique chemical duality of OH-PDLA-COOH for innovating in areas such as targeted drug delivery, advanced polymer architectures, and functional surface design, where control over both reactivity and degradation is paramount.