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BP10987 PLGA 50:50, Hydroxyl Terminated, IV ≤ 0.18 dl/g, Mw ≤ 15 kDa

Catalogue Number BP10987
CAS Number 26780-50-7
Composition Poly(D, L-lactide-co-glycolide) 50:50, Hydroxyl Terminated
Form Powder

BP10987 is a low molecular weight PLGA 50:50 copolymer distinguished by its standard hydroxyl (-OH) termination, with an intrinsic viscosity (IV) ≤ 0.18 dl/g and a molecular weight (Mw) ≤ 15 kDa. The hydroxyl end group introduces a polar and hydrophilic site, enhancing the material's compatibility with aqueous and polar formulations while providing a reactive handle for potential chemical conjugation or cross-linking. This versatile material is engineered for applications that benefit from enhanced hydrophilicity, facile processing, and tunable functionality. Stanford Advanced Materials (SAM) ensures batch-to-batch consistency through controlled synthesis, supporting reliable and sustainable product development.

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FAQ

What are the key features and advantages of hydroxyl termination?

Hydroxyl termination provides a polar and hydrophilic functional group (-OH) at the polymer chain end. This enhances the material’s compatibility with water-based systems, can influence initial degradation rates, and, most importantly, provides a versatile reactive site for chemical modification, enabling grafting, cross-linking, or conjugation with other molecules.

What is the typical degradation time for this material?

Due to its low molecular weight (Mw ≤ 15 kDa) and hydrophilic end group, this grade is designed for relatively rapid degradation, typically ranging from several weeks to a few months under physiological or ambient environmental conditions. The hydroxyl group may facilitate initial water uptake, potentially accelerating the onset of degradation compared to more hydrophobic equivalents.

How does the hydroxyl end group affect compatibility and processing?

The hydroxyl end group significantly enhances the polymer’s hydrophilicity, improving its wettability, dispersion in polar solvents, and compatibility with other hydrophilic components in a formulation. Combined with its low intrinsic viscosity (≤ 0.18 dl/g), this allows for easy processing in aqueous or polar solvent systems for spraying, coating, or film formation.

In which applications is this hydroxyl-terminated grade most suitable?

This grade is particularly suitable for applications that leverage its hydrophilicity and chemical reactivity. These include biodegradable binders for paper/cellulose, delivery systems for hydrophilic actives in personal care, precursors for synthesising functionalised block copolymers, and formulations where enhanced aqueous compatibility is required.

Can you provide PLGA with varying molecular weights or other terminal groups?

Yes. We offer a detailed portfolio of PLGA copolymers with varied monomer ratios, molecular weights, and terminal functionalities (including carboxyl, various ester terminations, and other custom groups). Please contact our technical sales team to discuss custom specifications.

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