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BP10988 PLGA 50:50, Hydroxyl Terminated, IV: 0.18–0.55 dl/g, Mw: 15–70 kDa

Catalogue Number BP10988
CAS Number 26780-50-7
Composition Poly(D, L-lactide-co-glycolide) 50:50, Hydroxyl Terminated
Form Powder

BP10988 is a medium molecular weight PLGA 50:50 copolymer characterised by its standard hydroxyl (-OH) termination, with an intrinsic viscosity (IV) range of 0.18–0.55 dl/g and a molecular weight (Mw) range of 15–70 kDa. The hydroxyl end group introduces a polar and hydrophilic site, enhancing the material's compatibility with aqueous and polar formulations while providing a reactive handle for chemical modification. This material is engineered for applications requiring a balance of mechanical strength, processability, and enhanced interaction with polar systems. Stanford Advanced Materials (SAM) ensures batch-to-batch consistency through controlled synthesis, supporting reliable and sustainable product development.

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FAQ

What are the key features and advantages of hydroxyl termination?

Hydroxyl termination provides a polar and hydrophilic functional group (-OH) at the polymer chain end. This enhances the material’s compatibility with water-based and polar systems, can influence its interfacial properties and degradation profile, and provides a versatile reactive site for chemical grafting, cross-linking, or conjugation.

What is the typical degradation time for this material?

Due to its medium molecular weight range (15–70 kDa), this grade is designed for intermediate-term degradation, typically ranging from a few months to over a year under physiological or ambient conditions. The hydrophilic hydroxyl group may facilitate initial hydration, influencing the degradation onset compared to more hydrophobic counterparts.

How does the medium viscosity and hydroxyl end group affect processing?

The moderate intrinsic viscosity (0.18–0.55 dl/g) provides good solubility with sufficient solution viscosity for film casting or fibre processing. The hydroxyl end group enhances compatibility with polar solvents and substrates, thereby facilitating formulation in systems requiring improved wetting or adhesion to hydrophilic surfaces.

In which applications is this hydroxyl-terminated grade most suitable?

This grade is ideal for applications that leverage its balance of mechanical properties, processability, and hydrophilic reactivity. These include functional binders for cellulose composites, carriers for hydrophilic actives in sustained-release systems, and as a precursor for synthesising higher-order functional polymers.

Can you supply PLGA with different molecular weights or other end groups?

Yes. We offer a detailed portfolio of PLGA copolymers with various monomer ratios, molecular weights, and terminal functionalities (including carboxyl and various ester terminations). Please contact our technical sales team to discuss bespoke specifications.

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