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BP10989 PLGA 50:50, Hydroxyl Terminated, IV ≥ 0.55 dl/g, Mw ≥ 70 kDa

Catalogue Number BP10989
CAS Number 26780-50-7
Composition Poly(D, L-lactide-co-glycolide) 50:50, Hydroxyl Terminated
Form Powder

BP10989 is a high molecular weight PLGA 50:50 copolymer characterized by its standard hydroxyl (-OH) termination, with an intrinsic viscosity (IV) ≥ 0.55 dl/g and a molecular weight (Mw) ≥ 70 kDa. The hydroxyl end group introduces a polar and hydrophilic site, which can influence the initial hydration and interfacial properties of the polymer, while also providing a reactive handle for potential chemical modification. This material is engineered for industrial and functional applications requiring durable mechanical performance, extended structural integrity, and precisely tailored release kinetics. Stanford Advanced Materials (SAM) ensures consistent quality through controlled synthesis, supporting sustainable and reproducible product development. 

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FAQ

What are the key features and advantages of hydroxyl termination?

Hydroxyl termination provides a polar and hydrophilic functional group (-OH) at the polymer chain end. This influences the material’s surface properties and initial interaction with aqueous environments. More importantly, it serves as a versatile reactive site for chemical conjugation, cross-linking, or grafting, enabling the creation of advanced functional materials with tailored properties.

What is the typical degradation time for this high molecular weight grade?

Due to its high molecular weight (Mw ≥ 70 kDa), this grade is inherently designed for long-term degradation, typically ranging from several months to multiple years. The hydrophilic hydroxyl group may affect the very initial stage of water penetration, but the overall degradation rate is predominantly governed by the long polymer chains and high crystallinity potential.

How do the high viscosity and hydroxyl end group influence processing?

The high intrinsic viscosity (≥ 0.55 dl/g) provides excellent melt strength and solution rheology, suitable for extrusion, moulding, and high-solids coatings. The hydroxyl end group can enhance compatibility with certain polar additives or substrates, and offers a chemical handle for post-processing modification or cross-linking to further improve performance.

In which applications is this hydroxyl-terminated, high molecular weight grade most suitable?

This grade is ideal for high-performance applications that benefit from its durability, processability, and the synthetic versatility provided by the hydroxyl group. These include high-strength biodegradable composites, long-lasting functional coatings requiring adhesion to polar surfaces, and as a macromolecular building block for synthesising advanced polymeric architectures.

Can you supply PLGA with different molecular weights or other terminal groups?

Yes. We offer a detailed portfolio of PLGA copolymers with varied monomer ratios, molecular weights, and terminal functionalities (including carboxyl and various ester terminations). Please contact our technical sales team to discuss custom synthesis for your specific requirements.

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