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BP10994 PLGA 75:25, Lauryl Ester Terminated, IV: 0.18–0.75 dl/g, Mw: 15–106 kDa

Catalogue Number BP10994
CAS Number 26780-53-0
Composition Poly(D, L-lactide-co-glycolide) 75:25, Lauryl Ester Terminated
Form Powder

BP10994 is a medium-to-high molecular weight PLGA 75:25 copolymer with standard lauryl ester termination, characterised by an intrinsic viscosity (IV) range of 0.18–0.75 dl/g and a molecular weight (Mw) range of 15–106 kDa. The combination of a higher lactide ratio (75:25) and increased molecular weight endows this material with enhanced mechanical strength, an extended degradation cycle, and improved structural durability compared to medium Mw 50:50 PLGA. The lauryl ester end group enhances hydrophobicity, providing controllable degradation kinetics and improved compatibility with non-polar systems. This material is engineered for biomedical and industrial applications requiring long-term durability and mechanical properties or extended release. Stanford Advanced Materials (SAM) ensures consistent quality through controlled polymerisation processes, supporting sustainable and reproducible product development. Products within specific molecular weight sub-grades or with custom end-group modifications are available upon request.

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FAQ

What are the key advantages of medium-to-high molecular weight PLGA 75:25 compared to its low Mw counterpart?

The primary advantages are significantly enhanced mechanical strength, longer-lasting structural integrity, and a slower degradation rate (typically spanning several months to over a year). This makes it suitable for applications requiring durable support structures, long-term implants, or ultra-long-acting drug delivery systems.

What is the specific role of lauryl ester termination in this high Mw PLGA?

The lauryl ester end group reinforces the inherent hydrophobicity of the high molecular weight PLGA. It more effectively delays initial hydration, provides additional protection to the polymer chains, and enables finer control over the onset and rate of degradation, while also optimising compatibility with lipophilic drugs or matrices.

What processing methods are suitable for this viscosity range?

The intrinsic viscosity range of 0.18–0.75 dl/g offers excellent processing versatility. It is suitable for both solvent-based techniques such as solvent casting and electrospinning to produce uniform films or fibrous scaffolds, and for thermal processing methods such as melt extrusion or injection moulding to fabricate solid implants or devices with precise shapes and good mechanical properties.

Can I select a specific molecular weight sub-grade?

Yes. We offer six precise molecular weight sub-grades (15–106 kDa), each with a corresponding IV range. You can select the most appropriate sub-grade to optimise your application based on the target degradation rate and required mechanical performance.

Is this material suitable for load-bearing biomedical implants?

It possesses excellent mechanical properties among biodegradable polymers and is suitable for semi-structural implants, bone fixation devices, and tissue engineering scaffolds. However, for primary load-bearing applications, thorough mechanical testing and evaluation specific to the design, implantation site, and required support duration are essential. Customers must validate in accordance with the regulatory requirements of their target markets.

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