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BP10996 PLGA 75:25, Hydroxyl Terminated, IV ≤ 0.18 dl/g, Mw ≤ 15 kDa

Catalogue Number BP10996
CAS Number 26780-53-0
Composition Poly(D, L-lactide-co-glycolide) 75:25, Hydroxyl Terminated
Form Powder

BP10996 is a low molecular weight PLGA 75:25 copolymer with standard hydroxyl (-OH) termination, characterised by an intrinsic viscosity (IV) ≤ 0.18 dl/g and a molecular weight (Mw) ≤ 15 kDa. The hydroxyl end group enhances the material's hydrophilicity and provides a versatile reactive site for further chemical modifications. This combination of controlled molecular weight, defined monomer ratio, and functional end-group makes it an ideal material for applications requiring predictable degradation, aqueous compatibility, and synthetic versatility in advanced formulations.

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FAQ

What are the key features and advantages of hydroxyl termination in this PLGA 75:25?

Hydroxyl termination provides a polar and hydrophilic functional group (-OH) at the polymer chain end. This enhances the material's compatibility with water-based systems and polar substrates, can influence initial degradation rates by facilitating water uptake, and, most importantly, serves as a versatile reactive site for chemical modification, enabling grafting, cross-linking, or conjugation with other molecules.

How does the 75:25 monomer ratio influence the degradation profile of this material?

The 75:25 lactide-to-glycolide ratio provides a slower hydrolytic degradation rate compared to glycolide-rich compositions. This results in a more extended functional lifespan, making it suitable for applications that benefit from sustained release or structural support over an intermediate timeframe.

How does the hydroxyl end group affect compatibility and processing?

The hydroxyl end group significantly enhances the polymer's hydrophilicity, improving its wettability, dispersion in polar solvents (including aqueous mixtures with co-solvents), and compatibility with other hydrophilic components in a formulation. Combined with its low intrinsic viscosity (≤ 0.18 dl/g), this allows for easy processing in polar solvent systems for spraying, coating, or the formation of thin films and microcapsules.

In which applications is this hydroxyl-terminated PLGA 75:25 most suitable?

This grade is particularly suitable for applications that leverage its combination of hydrophilicity, chemical reactivity, and an intermediate degradation timeline. These include drug delivery systems for hydrophilic actives requiring sustained release over several weeks, hydrophilic tissue engineering scaffolds, biodegradable binders for polar substrates, and as a reactive macroinitiator for synthesising functionalised block copolymers.

Can you supply PLGA 75:25 with different molecular weights or other end groups?

Yes. We offer a detailed portfolio of PLGA copolymers with varied molecular weights and terminal functionalities (including carboxyl, lauryl ester, and other custom groups). Please contact our technical sales team to discuss custom specifications.

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