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BP11001 PLGA 75:25, Carboxyl-Terminated, IV ≥ 0.75 dl/g, Mw ≥ 106 kDa

Catalogue Number BP11001
CAS Number 26780-53-0
Composition Poly(D, L-lactide-co-glycolide) 75:25, Carboxyl-Terminated
Form Powder

BP11001 is a carboxyl-terminated PLGA 75:25 copolymer with high intrinsic viscosity (IV ≥ 0.75 dl/g) and molecular weight (Mw ≥ 106 kDa). Engineered for applications requiring extended durability and predictable long-term degradation, this grade utilises the inherent strength of high Mw PLGA 75:25, while the carboxyl end group enhances hydrophilicity and provides a reactive site for chemical functionalisation. Stanford Advanced Materials (SAM) employs stringent analytical controls to ensure batch-to-batch consistency, making it a platform for advanced biomedical devices and high-performance functional materials.

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FAQ

How do the high molecular weight (≥ 106 kDa) and carboxyl termination work together?

The high molecular weight ensures prolonged mechanical integrity and a slow, extended degradation timeline (often >1 year). The carboxyl termination accelerates initial surface hydration and hydrolysis, whilst providing a reactive handle for chemical modification. This combination is ideal for long-life implants that also require biofunctionalisation or controlled drug elution.

What are the key processing considerations for this high IV (≥ 0.75 dl/g) PLGA?

The high intrinsic viscosity results in high melt and solution viscosities. It is well-suited for melt-processing techniques such as extrusion and injection moulding to create strong, solid implants. For solution processing, higher solvent concentrations or elevated temperatures may be required. Its excellent green strength also supports techniques such as 3D printing of high-resolution scaffolds.

How do I select among the different high Mw sub-grades?

The sub-grades allow precise matching of degradation rate and mechanical properties to your application. Grades around 100-200 kDa offer an optimal balance for many long-term implants. Ultra-high Mw grades (>400 kDa) provide maximum strength and longevity for load-bearing applications. Our technical team can assist in selection based on your specific requirements.

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