BP11113 PTMC, Poly(trimethylene carbonate), Carboxyl-Terminated, IV: 1.0–2.0 dl/g, Mw: 49–118 kDa

PTMC, Poly(trimethylene carbonate), Carboxyl-Terminated, IV: 1.0–2.0 dl/g, Mw: 49–118 kDa Description

PTMC, Poly(trimethylene carbonate) is a biodegradable polymer with terminal carboxyl groups that allow for subsequent chemical modifications. The intrinsic viscosity and molecular weight range are critical factors that influence processing parameters such as solvent compatibility and melt flow behaviour. Its controlled hydrolytic degradation profile makes it suitable for applications where temporary structural integrity is essential.

PTMC, Poly(trimethylene carbonate), Carboxyl-Terminated, IV: 1.0–2.0 dl/g, Mw: 49–118 kDa Applications

Healthcare
- Used as a matrix in bioresorbable scaffolds to achieve controlled tissue integration by leveraging its hydrolytic degradation properties.
- Applied as a drug delivery carrier in implantable devices to modulate release profiles through predictable degradation kinetics.

Industrial
- Serves as an additive in coating formulations to achieve controlled surface reactivity by utilising its reactive carboxyl terminations.

PTMC, Poly(trimethylene carbonate), Carboxyl-Terminated, IV: 1.0–2.0 dl/g, Mw: 49–118 kDa Packing

The polymer is supplied in sealed, inert packaging designed to protect against moisture and contamination. It is recommended to store the material in a cool, dry environment with anti-static precautions to preserve its properties. Customised packaging options, including vacuum-sealed and tamper-evident containers, are available to address specific handling and storage requirements.

Additional Information

HO-PTMC-COOH is a heterotelechelic derivative of poly(trimethylene carbonate) (PTMC), a biodegradable and biocompatible polymer widely studied in the field of biomedical materials. Known for its amorphous nature, it exhibits excellent biocompatibility and biodegradability, and remains in a rubbery state with inherent elasticity at body temperature. Its adjustable degradation profile and processability make it well-suited for applications such as soft tissue engineering, flexible implants, and controlled drug delivery systems. Understanding the relationship between its molecular weight and intrinsic viscosity is essential for tailoring its performance in specific biomedical and industrial contexts.

Unlike conventional PTMC diols, the unique heterobifunctional structure of HO-PTMC-COOH—featuring both hydroxyl (-OH) and carboxyl (-COOH) terminal groups—provides two distinct and orthogonally reactive sites. This enables sequential, directional chemical modifications, such as selective chain extension from the hydroxyl end, followed by targeted conjugation of bioactive molecules, ligands, or other polymers via the carboxyl group. This controlled functionality significantly enhances its versatility in synthesising precisely defined architectures, including asymmetric block copolymers, surface-functionalised materials, and tunable cross-linked networks for advanced biomaterial design.

The dual reactivity of HO-PTMC-COOH expands its utility in advanced manufacturing, formulation processes, and the development of highly customised polymeric systems, particularly where spatial control over chemical functionality is required. Ongoing research continues to refine processing and conjugation techniques to enhance its performance, reliability, and reproducibility across a growing range of applications, from drug-polymer conjugates to modular tissue engineering scaffolds.

Regulatory Note: This material is intended for industrial and research applications. It is the customer's responsibility to ensure compliance with all relevant safety and regulatory standards in their intended use.