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BP11121 PLGA 65:35, Lauryl Ester Terminated, IV: 0.18–0.25 dl/g, Mw: 15–24 kDa

Catalogue Number BP11121
Composition Poly(D, L-lactide-co-glycolide) 65:35, Lauryl Ester Terminated
Form Powder

PLGA 65:35, Lauryl Ester Terminated is a functionalised biodegradable copolymer with a lactide-to-glycolide molar ratio of 65:35. The incorporation of lauryl ester end groups enhances the polymer's hydrophobicity and effectively modulates its degradation kinetics, making it particularly suitable for sustained-release formulations and hydrophobic drug delivery systems.

Stanford Advanced Materials (SAM) employs controlled synthesis processes and rigorous quality assurance systems, supported by spectroscopic and chromatographic characterisation methods. Intrinsic viscosity is determined using Ubbelohde capillary viscometry, providing key insights into polymer chain length and solution behaviour. Each batch undergoes validated analytical testing to ensure structural consistency, functional reliability, and compliance with specifications for advanced biomedical research and product development.

In addition to the standard 65:35 grade, SAM offers customised synthesis of PLGA copolymers with various lactide-to-glycolide ratios, such as 90:10, 85:15, 80:20, 70:30, 65:35, and 60:40. We also provide tailored molecular weights, end-group modifications, and physical forms to meet diverse application requirements.

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FAQ

How does the lauryl ester termination affect the degradation rate of PLGA?

The lauryl ester termination modifies the hydrophobicity of the polymer, which can slow hydrolytic degradation. This controlled degradation rate is beneficial where a gradual resorption in biomedical applications is required. Sampling analysis and in-vitro hydrolysis tests provide data to calibrate performance.

What methods are used to control the molecular weight distribution of this copolymer?

The molecular weight distribution is managed using controlled ring-opening polymerisation. Process parameters such as monomer feed ratio and catalyst concentration are monitored. Gel permeation chromatography is typically employed to verify consistency across production batches.

Can this PLGA be processed in standard biomedical manufacturing protocols?

Yes, its powder form facilitates solvent casting, extrusion, and moulding techniques common in biomedical device fabrication. The material’s defined intrinsic viscosity and molecular weight support reproducible processing, although optimal solvent selection should be confirmed for specific formulations. Contact us for further technical details.

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