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BP11126 PLGA 65:35, Lauryl Ester Terminated, IV: 0.65–0.8 dl/g, Mw: 88–117 kDa

Catalogue Number BP11126
Composition Poly(D, L-lactide-co-glycolide) 65:35, Lauryl Ester Terminated
Form Powder

PLGA 65:35, Lauryl Ester Terminated is a functionalised biodegradable copolymer with a lactide-to-glycolide molar ratio of 65:35. The incorporation of lauryl ester end groups enhances the polymer's hydrophobicity and modulates its degradation kinetics, making it suitable for sustained-release formulations and hydrophobic drug delivery systems.

Stanford Advanced Materials (SAM) employs controlled synthesis processes and rigorous quality assurance systems, supported by spectroscopic and chromatographic characterisation methods. Intrinsic viscosity is determined using Ubbelohde capillary viscometry, providing insights into polymer chain length and solution behaviour. Each batch undergoes validated analytical testing to ensure structural consistency, functional reliability, and compliance with specifications for advanced biomedical research and product development.

In addition to the standard 65:35 grade, SAM offers customised synthesis of PLGA copolymers with various lactide-to-glycolide ratios, such as 90:10, 85:15, 80:20, 70:30, 65:35, and 60:40. We also provide tailored molecular weights, end-group modifications, and physical forms to meet diverse application requirements.

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FAQ

How does the lauryl ester termination affect the degradation profile of the polymer?

The lauryl ester termination modifies the polymer’s hydrophobicity and influences its degradation rate by reducing water absorption. This adjustment can be critical when tuning the polymer for specific biomedical applications, such as controlled drug release.

What factors should be considered when processing PLGA 65:35 into usable forms?

Key considerations include the polymer’s intrinsic viscosity and molecular weight, as these properties influence solubility, melt processing behaviour, and mechanical integrity. Adjusting processing parameters can help achieve the desired pore structure and material performance.

Can PLGA 65:35 be sterilised without compromising its structural integrity?

Yes, PLGA 65:35 can be sterilised using methods such as gamma irradiation or ethylene oxide treatment. However, careful control is necessary to prevent chain scission and alterations in molecular weight that may affect its mechanical and degradation properties. Contact us for further details.

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