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BP11133 PLGA 65:35, Carboxyl-Terminated, IV: 0.35–0.45 dl/g, Mw: 38–53 kDa

Catalogue Number BP11133
Composition Poly(D, L-lactide-co-glycolide) 65:35, Carboxyl-Terminated
Form Powder

PLGA 65:35, Carboxyl-Terminated, IV: 0.35–0.45 dl/g, Mw: 38–53 kDa is a biocompatible polymer designed for applications that require predictable degradation. Manufactured by Stanford Advanced Materials (SAM), this product is synthesised under stringent quality control protocols that include routine gel permeation chromatography and end-group analysis. SAM's controlled batch processing and comprehensive inspection routines ensure reproducibility and consistency in product performance.

In addition to the standard 65:35 grade, SAM offers customised synthesis of PLGA copolymers with various lactide-to-glycolide ratios, such as 90:10, 85:15, 80:20, 70:30, 65:35, and 60:40. We also provide tailored molecular weights, end-group modifications, and physical forms to meet diverse application requirements.

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FAQ

How does the molecular weight range of 38–53 kDa influence the degradation rate of PLGA?

The specified molecular weight range influences the polymer’s hydrolysis rate. A controlled molecular weight ensures a predictable degradation profile, which is essential for applications in controlled drug release and tissue engineering scaffolds.

What are the implications of carboxyl termination on PLGA performance in biomedical settings?

Carboxyl termination increases the hydrophilicity of the polymer, which can improve the rate of hydrolytic degradation. This facilitates a more uniform erosion process, which is advantageous in applications such as resorbable sutures or implantable devices.

What processing considerations should be made when utilising PLGA in biomedical applications?

It is important to control processing parameters such as temperature and solvent removal during fabrication. These factors ensure that the polymer’s molecular structure is maintained, preserving its degradation kinetics and mechanical properties for consistent biomedical performance.

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