BP11135 PLGA 65:35, Carboxyl-Terminated, IV: 0.55–0.65 dl/g, Mw: 70–88 kDa

Catalogue Number	BP11135
Composition	Poly(D, L-lactide-co-glycolide) 65:35, Carboxyl-Terminated
Form	Powder

PLGA 65:35, Carboxyl-Terminated, IV: 0.55–0.65 dl/g, Mw: 70–88 kDa is a biocompatible copolymer engineered for controlled degradation in biomedical settings. Stanford Advanced Materials (SAM) employs precise polymerisation monitoring and conducts impurity analysis using GPC and NMR to maintain batch consistency. Production protocols include intermediate quality checks that ensure compositional fidelity, essential for research and the development of bioresorbable devices.

In addition to the standard 65:35 grade, SAM offers customised synthesis of PLGA copolymers with various lactide-to-glycolide ratios, such as 90:10, 85:15, 80:20, 70:30, 65:35, and 60:40. We also provide tailored molecular weights, end-group modifications, and physical forms to meet diverse application requirements.

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How does the copolymer ratio influence the degradation profile?

The 65:35 lactide to glycolide ratio influences the hydrolysis rate; a higher glycolide content increases degradation speed. This allows for the optimisation of the degradation process for applications such as controlled drug release.

What processing challenges are associated with powder-form PLGA?

Powdered PLGA may exhibit agglomeration and inconsistent dispersion. Careful control of humidity and the use of dispersion aids during processing can help maintain uniformity.

Is it possible to adjust the molecular weight during polymerisation?

Yes, adjusting reaction conditions—such as catalyst concentration and temperature—can modify the molecular weight range. This change influences both mechanical properties and degradation time. Contact us for further details.

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Specification	Details
Material Description	65:35 D, L-PLGA with carboxylic acid end group
Appearance	White to pale-yellow powder or granules
Glass Transition Temperature (Tg)	45–55°C (Typical)
Molecular Weight (Mw)	70–88 kD
Intrinsic Viscosity (IV)	0.55–0.65 dl/g
Loss on Drying	≤ 0.5 %
Residue on Ignition	≤ 0.5 %
Total Heavy Metals	≤ 10 ppm
Catalyst Residue	≤ 200 ppm
Monomer Residue	≤ 1 %

BP11135 PLGA 65:35, Carboxyl-Terminated, IV: 0.55–0.65 dl/g, Mw: 70–88 kDa

PLGA 65:35, Carboxyl-Terminated, IV: 0.55–0.65 dl/g, Mw: 70–88 kDa Description

PLGA 65:35, Carboxyl-Terminated, IV: 0.55–0.65 dl/g, Mw: 70–88 kDa Applications

PLGA 65:35, Carboxyl-Terminated, IV: 0.55–0.65 dl/g, Mw: 70–88 kDa Packing

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FAQ

How does the copolymer ratio influence the degradation profile?

What processing challenges are associated with powder-form PLGA?

Is it possible to adjust the molecular weight during polymerisation?

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