BP11137 PLGA 65:35, Carboxyl-Terminated, IV: 0.8–1.0 dl/g, Mw: 117–158 kDa

PLGA 65:35, Carboxyl-Terminated, IV: 0.8–1.0 dl/g, Mw: 117–158 kDa Description

PLGA 65:35 is a copolymer of lactic acid and glycolic acid in a 65:35 ratio marked by carboxyl termination. The stated intrinsic viscosity of 0.8–1.0 dl/g relates to its chain length and solution behaviour, while the molecular weight range of 117–158 kDa governs its degradation rate and mechanical properties. This material is formulated for applications where controlled hydrolysis and sustained release are critical.

PLGA 65:35, Carboxyl-Terminated, IV: 0.8–1.0 dl/g, Mw: 117–158 kDa Applications

Healthcare Applications
   - Used as a matrix in biodegradable implants to achieve gradual drug release by leveraging controlled hydrolysis, solving burst release challenges and enhancing therapeutic effect.
   - Applied in microsphere formulations for sustained drug delivery by exploiting its consistent degradation rate to maintain drug concentration within therapeutic windows.

Pharmaceutical Manufacturing
   - Serves as an encapsulation medium in drug formulation processes to regulate release profiles by harnessing its predictable breakdown, reducing dose variability.
   - Employed in coating applications where its hydrophilic-hydrophobic balance addresses adherence issues, ensuring stable interaction with active pharmaceutical ingredients.

PLGA 65:35, Carboxyl-Terminated, IV: 0.8–1.0 dl/g, Mw: 117–158 kDa Packing

The polymer powder is packaged in moisture-resistant, sealed containers with inert liners to prevent contamination and maintain material integrity. The packaging is designed to support storage under cool, dry conditions, reducing the risk of premature degradation. For bulk orders, custom packaging solutions are available to meet specific storage and handling requirements.

Additional Information

Biodegradable polymers like PLGA are integral in controlled-release drug delivery systems. Their degradation behaviour is finely tuned by factors such as monomer ratio, intrinsic viscosity, and molecular weight, which determines their breakdown rate and mechanical properties. This understanding supports the development of implants and microspheres that require precise release profiles.

The study of polymer degradation kinetics remains a vital area in materials science and biomedical engineering. Insights from systematic testing, including GPC and NMR analysis, help optimise polymer performance for varied applications, ensuring that material characteristics align with desired therapeutic outcomes.

Regulatory Note: This material is intended for industrial and research applications. It is the customer's responsibility to ensure compliance with all relevant safety and regulatory standards in their intended use.