HA6995 Papaya Leaf Extract Powder

Papaya Leaf Extract Powder Description

Papaya Leaf Extract Powder is a hygroscopic fine powder, with a colour range from light brown to yellowish, exhibiting a slight herbal odour. Its primary bioactive components include flavonoids (quercetin, kaempferol), glycosides, and alkaloids (carpaine), along with enzymes such as papain and chymopapain. Flavonoids possess significant free-radical scavenging capability, reducing oxidative stress by inhibiting lipid peroxidation and enhancing glutathione synthesis. Alkaloids modify immune responses through TNF-α suppression and interleukin regulation, whereas carpaine specifically inhibits platelet aggregation and promotes thrombopoietin gene expression, contributing to platelet synthesis. The extract remains thermally stable below 60°C; degradation occurs at higher temperatures, necessitating low-heat processing. It demonstrates pH-dependent solubility, with optimal dissolution observed in hydroalcoholic solvents but limited stability in acidic gastric environments, which often requires enteric coating for oral formulations. Analytical profiles indicate trace amounts of glucosinolates and glutathione that enhance bioavailability. Residues of heavy metals are within pharmacopeial limits (lead ≤20 ppm, arsenic ≤3 ppm), while microbial contaminants are controlled to ensure safety. Stability necessitates protection from light and moisture, with a typical shelf life of 24 months under desiccated storage conditions at 15–25°C.

Papaya Leaf Extract Powder Applications

• Pharmaceuticals and Nutraceuticals: Formulated into capsules, syrups, and tablets to increase platelet count in conditions such as dengue fever and chemotherapy-induced thrombocytopenia. Its alkaloids stimulate bone marrow megakaryocyte activity, whilst flavonoids reduce viral replication in enveloped viruses, supporting adjunctive therapy for viral haemorrhagic fevers and immune rehabilitation.
• Functional Foods and Beverages: Incorporated into tonics aimed at boosting immunity and recovery drinks targeting metabolic health. Acts as a natural digestive aid due to the presence of the papain enzyme, which enhances protein breakdown and alleviates bloating in functional beverages and meal replacements.
• Cosmetics and Personal Care: Used in anti-inflammatory serums and creams suitable for acne-prone or sensitive skin. Flavonoids inhibit histamine release and COX-2 pathways to reduce redness, while antioxidants neutralise UV-induced free radicals, delaying photoageing in sunscreens and reparative moisturisers.
• Agriculture and Biopesticides: Employed as a natural insecticide against agricultural pests. Alkaloids interfere with larval development in Aedes aegypti mosquitoes and Spodoptera species, providing an environmentally friendly alternative to synthetic pesticides within integrated pest management systems.
• Biomedical Research and Diagnostics: Investigated for anticancer mechanisms by inducing apoptosis in solid tumours and leukemia cell lines. Carpaine exhibits dose-dependent cytotoxicity, while lectins serve as glycobiology tools for the detection of tumour-specific carbohydrate markers in histopathology assays.

Papaya Leaf Extract Powder Packaging

Our products are packaged in customised cartons of various sizes based on the material dimensions. Smaller items are securely packed in PP boxes, while larger items are placed in custom wooden crates. We strictly adhere to packaging customisation and utilize appropriate cushioning materials to ensure optimal protection during transportation.

Packaging: Carton, Wooden Box, or Customised.

Please review the packaging details provided for your reference.

Manufacturing Process

1.       Testing Method

(1)    Chemical Composition Analysis - Verified using techniques such as GDMS or XRF to ensure compliance with purity requirements.

(2)    Mechanical Properties Testing - Includes tensile strength, yield strength, and elongation tests to assess material performance.

(3)    Dimensional Inspection - Measures thickness, width, and length to ensure adherence to specified tolerances.

(4)    Surface Quality Inspection - Checks for defects such as scratches, cracks, or inclusions through visual and ultrasonic examination.

(5)    Hardness Testing - Determines material hardness to confirm uniformity and mechanical reliability.

Please refer to the SAM testing procedures for detailed information.

Papaya Leaf Extract Powder FAQs

Q1. Can this powder increase platelet count in dengue fever?

Clinical studies indicate platelet elevation within 24–48 hours at a dosage of 1,100 mg/day. It stimulates thrombopoietin genes; optimal results necessitate initiation at fever onset and continuation for 5 days post-recovery.

Q2. Is it safe with blood-thinning medications such as warfarin?

Concurrent use is not advised. Alkaloids may enhance anticoagulant effects, increasing the risk of bleeding. Consulting a healthcare provider before combining with any antiplatelet/anticoagulant medications is recommended.

Q3. How long until I observe immune benefits during the cold season?

Most users report fewer infections after 2–3 weeks of taking 500 mg daily. For acute illness, a dosage of 300 mg three times daily with zinc is advised to reduce illness duration.

Related Information

1.       Common Preparation Methods

The production of Papaya Leaf Extract Powder commences with sustainably farmed Carica papaya leaves, typically harvested from organic sources in tropical regions. Fresh leaves undergo washing with ozonated water to eliminate soil residues, followed by shade-drying at ≤40°C to maintain thermolabile enzymes. Dried leaves are milled into coarse particles and submitted to ethanol-water extraction (40–60% ethanol) at 50–55°C for 4–6 hours to solubilise flavonoids and alkaloids. The crude extract is filtered through ceramic membranes to eliminate chlorophyll and cellulose, then concentrated via vacuum evaporation at 45°C. Further purification uses macroporous resin chromatography to isolate target actives such as carpaine and quercetin glycosides while removing tannins and pesticides. The clarified liquid is standardised to 10–20% total flavonoids and spray-dried with rice maltodextrin as a carrier, resulting in a free-flowing powder. Rigorous quality control includes HPLC validation of alkaloid profiles, residual solvent testing (ethanol ≤5,000 ppm), heavy metal screening, and microbial analysis to ensure compliance with international safety standards for human consumption.