HA9007 Hypericin Powder

Hypericin Powder Description

Hypericin Powder appears as a dark red to violet crystalline solid with a faint aromatic odour. Hypericin Powder possesses a molecular weight of 504.45 g/mol and a melting point range of 320-325°C with decomposition. Hypericin Powder demonstrates intense absorption peaks at 545 nm and 590 nm in ethanol solutions. Hypericin Powder is insoluble in water but highly soluble in dimethyl sulfoxide (DMSO), achieving concentrations up to 50 mg/mL. Hypericin Powder exhibits fluorescence emission at 595 nm upon excitation at 590 nm. Hypericin Powder maintains stability for 36 months when stored at -20°C in amber vials under an inert atmosphere. Hypericin Powder degrades upon prolonged exposure to UV light or temperatures above 50°C. Hypericin Powder shows a logP value of 5.2, indicating high lipophilicity. Hypericin Powder confirms the absence of heavy metals (Pb<0.1ppm, Cd<0.05ppm) and microbial contamination (total count <100 CFU/g).

Hypericin Powder Applications

• Photodynamic Therapy: Utilised in oncology for selective cancer cell destruction under visible light irradiation.
• Antiviral Research: Investigated against enveloped viruses, including herpes and hepatitis, in pharmaceutical studies.
• Neuropharmacology: Studied for neurotransmitter modulation in depression and anxiety disorder research.
• Dermatology: Formulated in topical treatments for psoriasis and vitiligo under controlled light exposure.
• Diagnostic Imaging: Utilised as fluorescence markers in cellular imaging and biodistribution studies.

Hypericin Powder Packaging

Our products are packaged in customised cartons of various sizes based on the material dimensions. Small items are securely packed in PP boxes, while larger items are placed in custom wooden crates. We ensure strict adherence to packaging customisation and the use of appropriate cushioning materials to provide optimal protection during transportation.

Packaging: Carton, Wooden Box, or Customised.

Kindly review the packaging details provided for your reference.

Manufacturing Process

1.       Testing Method

(1)    Chemical Composition Analysis - Verified using techniques such as GDMS or XRF to ensure compliance with purity requirements.

(2)    Mechanical Properties Testing - Includes tensile strength, yield strength, and elongation tests to assess material performance.

(3)    Dimensional Inspection - Measures thickness, width, and length to ensure adherence to specified tolerances.

(4)    Surface Quality Inspection - Checks for defects such as scratches, cracks, or inclusions through visual and ultrasonic examination.

(5)    Hardness Testing - Determines material hardness to confirm uniformity and mechanical reliability.

Please refer to the SAM testing procedures for detailed information.

Hypericin Powder FAQs

Q1. How quickly does hypericin degrade when exposed to room light?

Significant degradation occurs within 2-4 hours; always handle under red light or in complete darkness.

Q2. Why is DMSO the preferred solvent over ethanol?

DMSO provides superior solubility (50mg/mL vs. 20mg/mL in ethanol) and enhances cellular uptake.

Q3. Why does your powder appear black, not red?

High-purity hypericin crystallises as dark aggregates. Redissolve in DMSO to verify red fluorescence—absence indicates degradation.

Related Information

1.       Common Preparation Methods

Hypericin Powder is synthesised via photoconversion of protohypericin under LED irradiation at 2–8°C in acetone/NaHCO₃ solution. The crude product is treated with a salt-forming reagent in methanol, heated to >40°C, and filtered to remove insolubles. The filtrate is cooled to induce crystallisation, washed with hexane/ethyl acetate, and vacuum-dried under nitrogen. Purification involves silica gel chromatography with ethyl acetate elution, followed by recrystallisation in methanol. Final purity (≥95%) is validated by HPLC, with residual solvents controlled below 5,000 ppm and heavy metals ≤20 ppm. Advanced biocatalytic methods employ engineered E. coli expressing oxygen-methyltransferases for enantioselective synthesis, yielding >90% hypericin with reduced photodegradation intermediates.