NR6894 Glycine Powder

Glycine Powder Description

Glycine Powder crystallizes as monoclinic prisms or free-flowing crystals with a molecular weight of 75.07 g/mol and decomposition at 233°C. As the simplest amino acid, its zwitterionic structure enables pH-dependent behavior (pI 5.97), acting as a weak acid (pKa₁=2.34) and base (pKa₂=9.60). It demonstrates excellent water solubility (25 g/100mL at 25°C), moderate solubility in pyridine, and negligible solubility in nonpolar solvents. Thermal analysis confirms stability below 200°C, with decarboxylation releasing methylamine above 233°C. Pharmaceutical grades exhibit stringent impurity controls: chloride ≤0.005%, sulfate ≤0.006%, heavy metals (Pb ≤1 ppm), and residual solvents ≤50 ppm per ICH Q3C. Hygroscopicity is minimal (<0.2% water uptake at 65% RH), ensuring powder flowability.

Glycine Powder Applications

Pharmaceuticals: Intravenous nutrient (1.5–2 g/day); cytoprotectant in ischemic stroke therapies; buffering agent in antacid formulations (5–10% w/w).

Food Technology: Flavor enhancer (E640) in beverages (≤0.5%); sweetener synergist; meat preservative inhibiting lipid oxidation.

Biotechnology: Component of cell culture media (e.g., DMEM); cryoprotectant for enzyme stabilization.

Industrial: Metal complexing agent in electroplating baths (0.5–3 g/L); pH regulator in cosmetic emulsions.

Glycine Powder Packaging

Our products are packaged in customized cartons of various sizes based on the material dimensions. Small items are securely packed in PP boxes, while larger items are placed in custom wooden crates. We ensure strict adherence to packaging customization and the use of appropriate cushioning materials to provide optimal protection during transportation.

Packaging: Carton, Wooden Box, or Customized.

Kindly review the packaging details provided for your reference.

Manufacturing Process

1.       Testing Method

(1)    Chemical Composition Analysis - Verified using techniques such as GDMS or XRF to ensure compliance with purity requirements.

(2)    Mechanical Properties Testing - Includes tensile strength, yield strength, and elongation tests to assess material performance.

(3)    Dimensional Inspection - Measures thickness, width, and length to ensure adherence to specified tolerances.

(4)    Surface Quality Inspection - Checks for defects such as scratches, cracks, or inclusions through visual and ultrasonic examination.

(5)    Hardness Testing - Determines material hardness to confirm uniformity and mechanical reliability.

Please refer to the SAM testing procedures for detailed information.

Glycine Powder FAQs

Q1. Why is glycine used in PCR buffers?

It minimizes DNA secondary structures by reducing electrostatic interactions (working concentration: 0.1–1 M), enhancing Taq polymerase processivity.

Q2. Can diabetics consume glycine-sweetened foods?

Yes. Glycine stimulates glucagon-like peptide-1 (GLP-1) without affecting insulin, making it suitable for diabetic diets (EFSA Opinion 2.4.2020).

Q3. How to prevent caking during storage?

Hygroscopicity increases above 70% RH. Store sealed at ≤65% RH; technical grades include 0.5% silica anti-caking agent.

Related Information

1.       Common Preparation Methods

Chemical Synthesis: Ammonia reacts with chloroacetic acid at 80°C, followed by neutralization with ammonium hydroxide. Crude glycine precipitates upon concentration.

Fermentation: Corynebacterium glutamicum metabolizes glucose to glycine via serine hydroxymethyltransferase.

Purification: Dissolution in boiling water, activated carbon decolorization, and recrystallization at pH 5.5–6.0.

Finishing: Vacuum-dried at 85°C to ≤0.1% moisture; milled to 90% particle size 50–150 μm.