NA6891 1‑Hexanesulfonic Acid Sodium Powder

1‑Hexanesulfonic Acid Sodium Powder Description

1‑Hexanesulfonic Acid Sodium Powder crystallizes as a hygroscopic solid with a molecular weight of 188.22 g/mol and a thermal decomposition onset at 285°C. The C6 alkyl chain provides optimal hydrophobicity for retaining analytes with log P values of 1.5–3.5 in reverse-phase chromatography, while the sulfonate group facilitates electrostatic interactions with protonated bases. It demonstrates excellent solubility in aqueous mobile phases (480 g/L in water) and methanol (110 g/L), but limited compatibility with acetonitrile (<10 g/L). HPLC-grade material maintains stringent specifications: UV absorbance (220 nm) ≤0.03 AU, sulfate ≤0.02%, heavy metals (Fe ≤0.1 ppm), and undetectable nuclease activity. The powder is stable for 36 months when stored desiccated at 15–25°C.

1‑Hexanesulfonic Acid Sodium Powder Applications

Pharmaceutical QC: Ion-pairing agent for antibiotics (tetracyclines, sulfonamides) and antivirals in USP-compliant assays; concentration range: 5–30 mM in C18 columns.

Neurochemistry: Critical for separating catecholamines (dopamine, norepinephrine) and serotonin in biological fluids via LC-ECD; enhances peak symmetry at 10–20 mM.

Environmental Analysis: Retains polar herbicides (atrazine, diuron) in EPA 535.1 methods; reduces matrix interference in water samples.

Food Safety: Detects artificial sweeteners (acesulfame-K, saccharin) in beverages per ISO 20636; mobile phase additive at 15 mM.

1‑Hexanesulfonic Acid Sodium Powder Packaging

Our products are packaged in customized cartons of various sizes based on the material dimensions. Small items are securely packed in PP boxes, while larger items are placed in custom wooden crates. We ensure strict adherence to packaging customization and the use of appropriate cushioning materials to provide optimal protection during transportation.

Packaging: Carton, Wooden Box, or Customized.

Kindly review the packaging details provided for your reference.

Manufacturing Process

1.       Testing Method

(1)    Chemical Composition Analysis - Verified using techniques such as GDMS or XRF to ensure compliance with purity requirements.

(2)    Mechanical Properties Testing - Includes tensile strength, yield strength, and elongation tests to assess material performance.

(3)    Dimensional Inspection - Measures thickness, width, and length to ensure adherence to specified tolerances.

(4)    Surface Quality Inspection - Checks for defects such as scratches, cracks, or inclusions through visual and ultrasonic examination.

(5)    Hardness Testing - Determines material hardness to confirm uniformity and mechanical reliability.

Please refer to the SAM testing procedures for detailed information.

1‑Hexanesulfonic Acid Sodium Powder FAQs

Q1. Why does retention time decrease after 10 injections?

Column fouling occurs due to irreversible adsorption of ion-pair complexes. Regenerate with 50:50 methanol/0.1% phosphoric acid at 0.5 mL/min for 60 minutes; use guard columns for complex matrices.

Q2. Can I use this reagent with mass spectrometry?

Yes for concentrations ≤15 mM. Higher concentrations suppress ionization; add 0.05% formic acid to enhance sensitivity for basic compounds. Avoid phosphate buffers to prevent salt deposition.

Q3. How to resolve precipitation in acetonitrile-rich mobile phases?

Precipitation occurs at >40% ACN. Prepare the mobile phase as an aqueous concentrate first, then add organic solvent. Filter through a 0.22 μm nylon membrane before use.

Related Information

1.       Common Preparation Methods

1‑Hexanesulfonic Acid Sodium Salt is synthesized through nucleophilic substitution of 1-bromohexane with sodium sulfite under reflux conditions (160°C, 8–12 hours). The crude product undergoes dissolution in hot ethanol, is treated with activated carbon to remove organic impurities, and is filtered. Recrystallization occurs in acetone/water (4:1 v/v) at -10°C. Crystals are vacuum-dried at 105°C for 24 hours to achieve ≤0.2% moisture, milled to 80% particle size <50 μm, and packaged under argon in amber glass vials to prevent oxidation.