NA6892 1‑Heptanesulfonic Acid Sodium Powder

1‑Heptanesulfonic Acid Sodium Powder Description

1‑Heptanesulfonic Acid Sodium Powder crystallizes as a hygroscopic solid with a molecular weight of 202.24 g/mol and a decomposition onset at 280°C. The C7 alkyl chain offers superior hydrophobicity for retaining analytes with log P values of 2.0–4.0 in reverse-phase chromatography, while the sulfonate group enables electrostatic pairing with protonated bases. It exhibits high solubility in aqueous phases (450 g/L in water) and methanol (100 g/L), but limited solubility in acetonitrile (<8 g/L). HPLC-grade material adheres to strict specifications: UV absorbance (220 nm) ≤0.02 AU, sulfate ≤0.01%, heavy metals (Fe ≤0.05 ppm), and undetectable enzymatic activity. Stability extends to 36 months when stored desiccated at 15–25°C.

1‑Heptanesulfonic Acid Sodium Powder Applications

Pharmaceutical Analysis: Ion-pairing agent for hydrophobic antibiotics (e.g., erythromycin) and steroids in USP-compliant methods; effective at 10–40 mM in C18 columns.

Lipidomics: Separates long-chain fatty acids and eicosanoids in biological matrices via LC-MS/MS; enhances sensitivity at 15–25 mM.

Environmental Monitoring: Retains PAHs (polycyclic aromatic hydrocarbons) and phenols in EPA 8310 methods; reduces co-elution in complex samples.

Food Chemistry: Analyzes synthetic dyes (Allura Red, Tartrazine) in confectionery per EU Regulation 1333/2008; mobile phase additive at 20 mM.

1‑Heptanesulfonic Acid Sodium Powder Packaging

Our products are packaged in customized cartons of various sizes based on the material dimensions. Small items are securely packed in PP boxes, while larger items are placed in custom wooden crates. We ensure strict adherence to packaging customization and the use of appropriate cushioning materials to provide optimal protection during transportation.

Packaging: Carton, Wooden Box, or Customized.

Kindly review the packaging details provided for your reference.

Manufacturing Process

1.       Testing Method

(1)    Chemical Composition Analysis - Verified using techniques such as GDMS or XRF to ensure compliance with purity requirements.

(2)    Mechanical Properties Testing - Includes tensile strength, yield strength, and elongation tests to assess material performance.

(3)    Dimensional Inspection - Measures thickness, width, and length to ensure adherence to specified tolerances.

(4)    Surface Quality Inspection - Checks for defects such as scratches, cracks, or inclusions through visual and ultrasonic examination.

(5)    Hardness Testing - Determines material hardness to confirm uniformity and mechanical reliability.

Please refer to the SAM testing procedures for detailed information.

1‑Heptanesulfonic Acid Sodium Powder FAQs

Q1. Why does column backpressure increase with extended use?

Ion-pair reagent accumulation in the column pores causes a pressure rise. Flush weekly with 70:30 methanol/water at 0.2 mL/min for 2 hours; use pre-column filters for complex samples.

Q2. How to prevent peak splitting in basic compound analysis?

Incomplete ion-pairing occurs at suboptimal pH. Adjust mobile phase to pH 3.0–3.5 with phosphoric acid; pre-mix reagent with buffer before adding organic solvent.

Q3. Can I replace this with octanesulfonate for stronger retention?

Yes, but C8 analogs increase analysis time by 35%. Use C7 for balanced resolution of mid-high hydrophobicity analytes (e.g., triglycerides, macrolides).

Related Information

1.       Common Preparation Methods

1‑Heptanesulfonic Acid Sodium Salt is synthesized via sulfonation of 1-bromoheptane with sodium sulfite at 150°C under nitrogen for 10 hours. The crude product is dissolved in hot isopropanol, treated with activated carbon, and filtered. Recrystallization occurs in ethyl acetate/water (5:1 v/v) at 5°C. Crystals are vacuum-dried at 100°C for 48 hours to achieve ≤0.1% moisture, milled to 90% particle size <45 μm, and packaged in argon-filled amber vials to prevent oxidation.