D‑Mannitol Powder Description
D-Mannitol Powder crystallizes as orthorhombic needles or
free-flowing granules with a molecular weight of 182.17 g/mol and decomposition
at 290°C. This six-carbon sugar alcohol exists in polymorphic forms
(β-modification preferred for tablets), featuring low hygroscopicity (<0.3%
moisture uptake at 65% RH) and negative heat of dissolution (-120 kJ/kg). It
demonstrates high water solubility (18.3 g/100mL at 25°C), moderate solubility
in glycerol, and insolubility in hydrocarbons. Thermal analysis confirms
stability below 250°C, with decomposition releasing formaldehyde and formic
acid above 290°C. Pharmacopeial grades maintain stringent controls: reducing
sugars ≤0.3%, heavy metals
(Pb ≤1 ppm), residual
solvents ≤50 ppm (ICH
Q3C), and endotoxin ≤0.5
EU/mg for injectables.
D‑Mannitol Powder Applications
Pharmaceuticals: Osmotic diuretic
for cerebral edema (15–25% IV solution); tablet diluent for chewable
formulations (30–90% w/w); lyoprotectant in freeze-dried biologics.
Food Technology: Bulking agent in
sugar-free confectionery (≤15%); anti-caking powder for chewing gum;
low-glycemic sweetener (60% sucrose sweetness).
Diagnostics: Matrix for dry
chemistry test strips; cryopreservation medium for cell banks.
Industrial: Dust suppression agent
in explosives; starter cultures for fermentation.
D‑Mannitol Powder Packaging
Our products are packaged in customized cartons of various
sizes based on the material dimensions. Small items are securely packed in PP
boxes, while larger items are placed in custom wooden crates. We ensure strict
adherence to packaging customization and the use of appropriate cushioning
materials to provide optimal protection during transportation.
Packaging: Carton, Wooden Box, or Customized.
Kindly review the packaging
details provided for your reference.
Manufacturing Process
1. Testing Method
(1) Chemical Composition Analysis - Verified using techniques
such as GDMS or XRF to ensure compliance with purity requirements.
(2) Mechanical Properties Testing - Includes tensile strength,
yield strength, and elongation tests to assess material performance.
(3) Dimensional Inspection - Measures thickness, width, and
length to ensure adherence to specified tolerances.
(4) Surface Quality Inspection - Checks for defects such as
scratches, cracks, or inclusions through visual and ultrasonic examination.
(5) Hardness Testing - Determines material hardness to confirm
uniformity and mechanical reliability.
Please refer to the SAM testing procedures for detailed information.
D‑Mannitol Powder FAQs
Q1. Why does mannitol cause a cooling sensation?
Its negative heat of solution (-120 kJ/kg) absorbs oral
cavity heat, creating a cooling effect 50% stronger than xylitol.
Q2. Can diabetics use mannitol-sweetened products?
Yes. With a glycemic index of 0 and negligible metabolism,
it’s suitable for diabetics (EFSA Opinion 2011). Limit to 20 g/day to avoid
laxative effects.
Q3. How to prevent tablet capping during compression?
β-Polymorph
(needle crystals) reduces elasticity. Use γ-form (granular) or blend with 5%
microcrystalline cellulose. Pre-dry at 80°C to <0.5% moisture.
Related Information
1. Common Preparation Methods
Catalytic Hydrogenation: Fructose solution (50–60%) reacts
with Raney nickel catalyst under H₂ (100–150 bar, 120–150°C), yielding a
mannitol/sorbitol mixture.
Separation: Crystallization at 10–15°C isolates mannitol;
mother liquor recycled for sorbitol recovery.
Fermentation: Lactobacillus intermedius converts fructose to
mannitol (yield >80%) at pH 5.0, 35°C.
Purification: Carbon treatment, ion-exchange, and
recrystallization from ethanol/water (1:2 v/v).
Milling: Jet-milled to 90% particles <100 μm; packaged
with desiccant.
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