NA6890 1‑Pentanesulfonic Acid Sodium Anhydrous Powder

1‑Pentanesulfonic Acid Sodium Anhydrous Powder Description

1-Pentanesulfonic Acid Sodium Salt Anhydrous Powder crystallizes as a hygroscopic white solid with a molecular weight of 174.19 g/mol and a decomposition onset at 290°C. The C5 alkyl chain provides optimal hydrophobicity for retaining polar compounds in reverse-phase chromatography, while the sulfonate group enables ion-pair formation with protonated analytes. It demonstrates high solubility in water (500 g/L) and methanol (120 g/L), but limited solubility in acetonitrile (<5 g/L). Thermal gravimetric analysis confirms stability below 200°C, with decomposition releasing sulfur oxides above 290°C. HPLC-grade variants exhibit stringent impurity controls: UV absorbance (220 nm) ≤0.05 AU, sulfate ≤0.02%, heavy metals (Fe ≤0.1 ppm), and nuclease activity undetectable.

1‑Pentanesulfonic Acid Sodium Anhydrous Powder Applications

Pharmaceutical Analysis: Ion-pairing agent for the separation of β-lactam antibiotics (e.g., penicillin G) and quinolones in C18 columns (5–25 mM concentration).

Biochemistry: Critical for nucleotide (ATP, GTP) and catecholamine (dopamine, epinephrine) quantification in biological matrices via LC-MS.

Environmental Testing: Enhances retention of polar pesticides (e.g., glyphosate) in EPA Method 547.1-compliant HPLC systems.

Food Safety: Detects sulfonamide residues in meat and dairy products per EU Regulation 37/2010.

1‑Pentanesulfonic Acid Sodium Anhydrous Powder Packaging

Our products are packaged in customized cartons of various sizes based on the material dimensions. Small items are securely packed in PP boxes, while larger items are placed in custom wooden crates. We ensure strict adherence to packaging customization and the use of appropriate cushioning materials to provide optimal protection during transportation.

Packaging: Carton, Wooden Box, or Customized.

Kindly review the packaging details provided for your reference.

Manufacturing Process

1.       Testing Method

(1)    Chemical Composition Analysis - Verified using techniques such as GDMS or XRF to ensure compliance with purity requirements.

(2)    Mechanical Properties Testing - Includes tensile strength, yield strength, and elongation tests to assess material performance.

(3)    Dimensional Inspection - Measures thickness, width, and length to ensure adherence to specified tolerances.

(4)    Surface Quality Inspection - Checks for defects such as scratches, cracks, or inclusions through visual and ultrasonic examination.

(5)    Hardness Testing - Determines material hardness to confirm uniformity and mechanical reliability.

Please refer to the SAM testing procedures for detailed information.

1‑Pentanesulfonic Acid Sodium Anhydrous Powder FAQs

Q1. Why choose pentanesulfonate over heptanesulfonate for HPLC?

The C5 chain provides balanced retention for moderately polar analytes (log P 0–2), while reducing analysis time by 40% versus C7/C8 analogs. It avoids excessive retention of early-eluting compounds like ascorbic acid.

Q2. How to prevent baseline noise in UV detection?

Always use HPLC-grade water (resistivity >18 MΩ·cm) for mobile phases. Filter solutions through 0.22 μm nylon membranes to remove particulates. Degas with helium sparging to eliminate CO₂-induced pH drift.

Q3. Can I use this for mass spectrometry?

Yes, but avoid concentrations >20 mM. High salt loads suppress ionization; supplement with 0.1% formic acid to enhance signal intensity for basic analytes.

Related Information

1.       Common Preparation Methods

Sulfonation: 1-Bromopentane reacts with sodium sulfite at 160°C under pressure to form sodium pentanesulfonate.

Purification: The Crude product undergoes activated carbon treatment, followed by recrystallization from ethanol/acetone (3:1 v/v).

Dehydration: Crystals are dried at 110°C under vacuum (≤1 mbar) for 48 hours to achieve ≤0.1% moisture.

Milling: Anhydrous crystals milled to 90% particles <75 μm; packaged in nitrogen-flushed amber vials.